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Database: UniProt
Entry: A0A1Q4VSE5_9ACTN
LinkDB: A0A1Q4VSE5_9ACTN
Original site: A0A1Q4VSE5_9ACTN 
ID   A0A1Q4VSE5_9ACTN        Unreviewed;       690 AA.
AC   A0A1Q4VSE5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=phospholipase C {ECO:0000256|ARBA:ARBA00012018};
DE            EC=3.1.4.3 {ECO:0000256|ARBA:ARBA00012018};
GN   ORFNames=A6A06_17560 {ECO:0000313|EMBL:OKI00747.1};
OS   Streptomyces sp. CB02923.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI00747.1, ECO:0000313|Proteomes:UP000185893};
RN   [1] {ECO:0000313|EMBL:OKI00747.1, ECO:0000313|Proteomes:UP000185893}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02923 {ECO:0000313|EMBL:OKI00747.1,
RC   ECO:0000313|Proteomes:UP000185893};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC         sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:10604,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC         ChEBI:CHEBI:57643, ChEBI:CHEBI:295975; EC=3.1.4.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00023550};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10605;
CC         Evidence={ECO:0000256|ARBA:ARBA00023550};
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000256|ARBA:ARBA00004191}.
CC   -!- SIMILARITY: Belongs to the bacterial phospholipase C family.
CC       {ECO:0000256|ARBA:ARBA00009717}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKI00747.1}.
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DR   EMBL; LWKZ01000024; OKI00747.1; -; Genomic_DNA.
DR   RefSeq; WP_073763493.1; NZ_LWKZ01000024.1.
DR   AlphaFoldDB; A0A1Q4VSE5; -.
DR   STRING; 1718985.A6A06_17560; -.
DR   OrthoDB; 4181857at2; -.
DR   Proteomes; UP000185893; Unassembled WGS sequence.
DR   GO; GO:0034480; F:phosphatidylcholine phospholipase C activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   GO; GO:0044003; P:modulation by symbiont of host process; IEA:UniProt.
DR   CDD; cd16014; PLC; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR017767; Bact_PC-PLC.
DR   InterPro; IPR007312; Phosphoesterase.
DR   InterPro; IPR008475; PLipase_C_C.
DR   InterPro; IPR006311; TAT_signal.
DR   NCBIfam; TIGR03396; PC_PLC; 1.
DR   PANTHER; PTHR31956:SF8; ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570); 1.
DR   PANTHER; PTHR31956; NON-SPECIFIC PHOSPHOLIPASE C4-RELATED; 1.
DR   Pfam; PF04185; Phosphoesterase; 1.
DR   Pfam; PF05506; PLipase_C_C; 2.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW   Reference proteome {ECO:0000313|Proteomes:UP000185893};
KW   Secreted {ECO:0000256|ARBA:ARBA00022512}.
FT   DOMAIN          501..587
FT                   /note="Bacterial phospholipase C C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05506"
FT   DOMAIN          594..674
FT                   /note="Bacterial phospholipase C C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05506"
FT   REGION          479..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  76149 MW;  0B516C68299DD9D3 CRC64;
     MPELNRRRFL QLTGGATAYS ALSQSIARAA AIPADRRTGT IEDIEHIVVL MQENRSFDHY
     FGTLCGVRGF GDPRPVTLPS GKPVWHQADK GGKEVLPFRP ETKDDYLGLT FIEDLNHDWN
     GSHQAFNKGR YDQWIPAKTS TTMAHLARKD IPFHFALADT FTVCDAYHCS FIGSTDPNRY
     YLWTGYTGND GKGVEDPSGP VLDNDERGYS WTTYPERLEA KGVSWKIYQD IGDGLDANGS
     WGWIKDHYRG NYGDNSLLYF NSYRNAKPGD PLYEKARRGS DVKKGGQLLD DLRADVKNGT
     LPKVSWIACP EAYTEHPSWP ANYGAWYISK VLDVLTSDPK VWSKTALFIT YDENDGFFDH
     VVPPYPPADA DQGRSTVSTE LELYPGGGGF QAGPYGLGQR VPMLVVSPWS TGGYVCSETF
     DHTSIIRFME RRFGVPEPHI SKWRRTVCGD LTSAFDFSGT GRPGTLPDTG GYTPIHPQPA
     DFHPRPPAHG SLPRQERGAR PTRPLPYEPY VDGAADVAAG KYRLTFSGGD AAGAQFYVTA
     PNRGDGPWTY TTERGKKDSD SWNTAYSNGT YDLSVFGPNG FLRTFRGPGK TAGPEVTARH
     DRATGNLDLV LTNAADGART LTLTDAYSGA SRKVTVRPGQ RVTHTVDLRA GKRWYDVSVV
     CDADRTFLRR FAGHVENGAA GVSDPAIRTV
//
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