ID A0A1Q4VSG3_9ACTN Unreviewed; 1551 AA.
AC A0A1Q4VSG3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:OKI00761.1};
GN ORFNames=A6A06_17645 {ECO:0000313|EMBL:OKI00761.1};
OS Streptomyces sp. CB02923.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI00761.1, ECO:0000313|Proteomes:UP000185893};
RN [1] {ECO:0000313|EMBL:OKI00761.1, ECO:0000313|Proteomes:UP000185893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02923 {ECO:0000313|EMBL:OKI00761.1,
RC ECO:0000313|Proteomes:UP000185893};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI00761.1}.
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DR EMBL; LWKZ01000024; OKI00761.1; -; Genomic_DNA.
DR RefSeq; WP_073763507.1; NZ_LWKZ01000024.1.
DR STRING; 1718985.A6A06_17645; -.
DR Proteomes; UP000185893; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000185893}.
FT DOMAIN 978..1052
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1551 AA; 161744 MW; 421C36421804CC6C CRC64;
MKTSTPATGP ASGKGSALAE VWPLSPLQEG MLFHAGFGDQ GPDVYVIQRT LTIDGPLDAA
RWRASWQALL ARHAALRASF HRRKSGEAVQ LITREAALPW READLSGLPE ADALAEVARL
AARECAERFD LGVAPLLRLL LVRLGDGRHC MVLTAHHILL DGWSMPILFD EATTAYAAGG
DATVLRRTAS YRDYLAWLGR QDKDAAREAW RAELSGDGEP TLVAPADPAR TPVLPDQAGA
DLPAGLTRAL TDLARRHGLT VNTVVQGAWA LLLARLSGRD DVVYGTTVAG RPPELPGVES
MVGLFINTVP VRVRLDAGQP VAEMLKNVQA RQSALLPHQH LGLADIQKHA GPGAGFDTLV
VYENYPRSAA GPGGPGTLTF TTLGLRQATH YPLTLGILPG DRLEVEVSYR PDLVTAGLAR
ALTGRLVRVL EQLVADPSVP VGRIGVLDAD ERHRAVEGWN VTAAATAGAT VPELFAARVA
SAPDAVAVAD GRQSVQYGRL DADSDRLAAY VSGSGVRRGD RVAVVMERSA GLIAALLGVW
KAGAAYVPVD AGYPAERIAF LLADSQPAAV LCTEATRAAV PADVSGQVIV LDDPKVRAAM
AEAPAVAPRP SVTAGDLAYV MYTSGSTGVP KGVGVPHGSV AALAGERGWE LGPDDAVLMH
APHAFDASLF EIWVPLVSGA RVAVAAAGAV DAQRVREAVA AGVTALHLTA GSFRVAAQED
PECFAGLREV LTGGDVVPAA SVARVREACP QVSVRHLYGP TEATLSATWH RLRPGGPVPD
VLPVGRPLAN RRAYVLDAFL HPVPPDVTGE LYLAGAGLAR GYLDRPGATA ERFTASPFVA
GERMYRTGDL ARRTPDGDLV FAGRADAQVK VRGYRIEPGE IEAVLAAAPG VAEAAVVARE
DRPGERRLVG YVVADGRDAD GPEPDGQALR EHVARTLPDY MVPAAVLVLD ALPVTANGKV
DRTALPAPGF AGKAAGRAPR TAAEDILCGL FAELLGLARV GAEDSFFRLG GDSIMSMQLA
TRARREGVVF SAQDVFEQET PGALAAVARL ADEVRAAPDA GLGEVAWTPG MTELGAYALS
SGFAQWMVVT TPAGLRPDVL TGGLAAVLDT HDMLRARVEH ADRGPRLVVP GRGTVDAAAL
LTRIDAADAP ATALDDLAER AAREATERLD TASGVLVQAV WLDAGPAEPG RLALVVHHLV
VDGVSWRILL PDLRAACEAL ADGRAPEPEP VVTSFREWAG ALAAQATEER RVAELPDWTA
VFEGVAPPLG GRALDPAEDT LAGMSRRTWT LPGATAATLV GKAPGVFHCG VHEVLLATLA
GAVARELPHG ALVVDIEGHG REPAAGADLS RTVGWFTSVH PVRLDVSGIA LDDASRGGPA
AGELLKRVKE QARAVPGDGL GHGLLRHLNP HTGPELDTLP GAHIGFNYLG RFAGAGRAAA
TGDAWQPAGT SVVGSSADPR TPAPHALEAG AYVQDGPDGP ELALVLGGPA GLWPDTAVER
LGRRWLDLLD GLAAHTADPA AGGHTASDFP LLDLGQDEVE EFEAGFTDGA P
//