ID A0A1Q4VSN3_9ACTN Unreviewed; 241 AA.
AC A0A1Q4VSN3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=rRNA N-glycosylase {ECO:0000256|ARBA:ARBA00012001};
DE EC=3.2.2.22 {ECO:0000256|ARBA:ARBA00012001};
GN ORFNames=A6A06_18185 {ECO:0000313|EMBL:OKI00841.1};
OS Streptomyces sp. CB02923.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI00841.1, ECO:0000313|Proteomes:UP000185893};
RN [1] {ECO:0000313|EMBL:OKI00841.1, ECO:0000313|Proteomes:UP000185893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02923 {ECO:0000313|EMBL:OKI00841.1,
RC ECO:0000313|Proteomes:UP000185893};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of the N-glycosidic bond at one specific
CC adenosine on the 28S rRNA.; EC=3.2.2.22;
CC Evidence={ECO:0000256|ARBA:ARBA00000237};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI00841.1}.
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DR EMBL; LWKZ01000024; OKI00841.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4VSN3; -.
DR Proteomes; UP000185893; Unassembled WGS sequence.
DR GO; GO:0030598; F:rRNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0017148; P:negative regulation of translation; IEA:InterPro.
DR Gene3D; 3.40.420.10; Ricin (A subunit), domain 1; 1.
DR InterPro; IPR036041; Ribosome-inact_prot_sf.
DR InterPro; IPR017989; Ribosome_inactivat_1/2.
DR InterPro; IPR001574; Ribosome_inactivat_prot.
DR InterPro; IPR016138; Ribosome_inactivat_prot_sub1.
DR PANTHER; PTHR33453; -; 1.
DR PANTHER; PTHR33453:SF48; RRNA N-GLYCOSYLASE; 1.
DR Pfam; PF00161; RIP; 1.
DR PRINTS; PR00396; SHIGARICIN.
DR SUPFAM; SSF56371; Ribosome inactivating proteins (RIP); 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000185893}.
SQ SEQUENCE 241 AA; 26228 MW; 743F64AE90609A77 CRC64;
MIGDLRTAAG HNVGNGVGAT ERLRADGARA VEIRLVNDNE SYASLYVQSD NLYMMGVWTP
SPHSGSVSGL VGFRDQRAEM QAILQRNGTP APVTDFGFNS NYDSLGSNRR AEVGMNGFTI
ADAARALHGY NPHMTHTQQA GFQAQLIILI QAVSEAARFQ DIAITVGNNI RNYASGQGTR
LSLNQVNMEN NWGNISGWLS AALDLPPDTI STTIEFGGEH FNNLDAFNRR FHYTLAKGSF
F
//
