ID A0A1Q4VTL7_9ACTN Unreviewed; 385 AA.
AC A0A1Q4VTL7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:OKI01172.1};
GN ORFNames=A6A06_20305 {ECO:0000313|EMBL:OKI01172.1};
OS Streptomyces sp. CB02923.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI01172.1, ECO:0000313|Proteomes:UP000185893};
RN [1] {ECO:0000313|EMBL:OKI01172.1, ECO:0000313|Proteomes:UP000185893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02923 {ECO:0000313|EMBL:OKI01172.1,
RC ECO:0000313|Proteomes:UP000185893};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI01172.1}.
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DR EMBL; LWKZ01000024; OKI01172.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4VTL7; -.
DR STRING; 1718985.A6A06_20305; -.
DR Proteomes; UP000185893; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06142; RNaseD_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR041605; Exo_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF18305; DNA_pol_A_exoN; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000313|EMBL:OKI01172.1};
KW Hydrolase {ECO:0000313|EMBL:OKI01172.1};
KW Nuclease {ECO:0000313|EMBL:OKI01172.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185893}.
FT DOMAIN 204..284
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 183..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 41518 MW; CF339D5FD68CAE34 CRC64;
MTATAEELAE VVSAFAAGTG PVAVDAERAS GYRYGQRAYL VQLRREGAGS VLIDPVGCPD
LSALGEAVAD AEWVLHAATQ DLPCLRDIGM IPARLFDTEL AGRLAGFARV GLGAMVENVL
GYALEKGHSA VDWSTRPLPE PWLRYAALDV ELLVDLRDAL EEELGRQGKL EWAHQEFAAI
AAAPPAPPRK DPWRRTSGMH KVRRRRQMAV VRELWTARDQ VAQRRDVSPG KVLGDAAIVE
AALNLPPNAH ALAGLNGFGH RMGRRQLEQW QAAVDRARAL PDSELPQPGQ ALNGPPPPRS
WADKDPAAAA RLSAARAAVT ALAEDLNLPQ ENLITPDTVR RLCWEPPAEP TEEAVADVLT
GHGARPWQVE QVAPILTEAL HTPGA
//
