ID A0A1Q4VYW5_9ACTN Unreviewed; 3158 AA.
AC A0A1Q4VYW5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMK13_28695 {ECO:0000313|EMBL:OKI03024.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI03024.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKI03024.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKI03024.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI03024.1}.
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DR EMBL; LIPD01000011; OKI03024.1; -; Genomic_DNA.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186379};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..433
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 934..1009
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1027..1453
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3005..3080
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 43..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3158 AA; 331390 MW; 01D48E2E8592CDCA CRC64;
MNSAGNRSVP EEPIALVGIS CRLPGAAGPR QLWDLLRDGR SAVTETPDDR RGGSGGPGDD
EPSALRWGAF LEDVDRFDAG FFGIGPREAA AMDPQQRLAL ELSWEAFEDA GIRPETWRSQ
DTAVFLGVAS GDYGLLLDRR GPAARTPHTV AGTQRGMTAN RVSYALGLHG PSLTVDAGQA
SSLAAVHLAC ESLRRGDSAL AVAGGVHLNL LPDTAHAMAG LGALSPDGRC FTFDERANGY
VRGEGGAMVV LKPLSRALAD GDPVYGVLLG SALNNDGGGE GLTVPARAGQ EEVLRRACAR
AGVDPAHVQY VELHGTGTRV GDPVEAAALG AVFGAARTAG QSPLHVGSVK TNVGHLEAAA
GVVGLVKVAL SLQHATLPPS LDFRTPNPLI DMDALRLRMV TDRLPWTGAD GTRLAGVSSF
GLGGTNCHVV LSQPPAPAAD TRAPADGGSG VVPWVLSGAT PEALRAQADR LRSYVAEEPD
AEPADVALAL ATTRATREHR AVVVAADREE FLRALTAAAE PGGVDPALVR GSVAEDGEVT
FVYPGQGSQW DGMARELLDT SAVFRERMEQ CDAALRPHVD WSLLDVLRGT PDAPPLERVD
VVQPALWAMM LALTEVWGSF GVRPDAVVGH SQGEIAAACV AGALSVEDGA RIVALRSRAL
GRLAGTGAMA TVSLPVAQVR DRLERGWDGV EIAAVNGPVS TVVSGPPGSV DRLLAEYEAE
GVWVRAIPVD YASHSGDVEV LRDALLTELA GITPRRSRIP FCSTVTGEIT DTTELDAGYW
YRNLRRPVRM ETATRHLLEA GHRTFVEVSP HPVLTVALQQ TVGAAAAVTG TLRRGEGGPR
RLLDSVARLH VRGARVDWQP ALRTGSGRRL RLPTYPFQRQ SYWLDGEDRR ETAAVDGRET
VAVDRRGPAV ADRRVPFGAE TGAPAPGPSR PGHGELTGLV REHAAAVLGH PEPGLVDTSR
RFKDLGFNSL DAVNLLERLT AATGVPLPPT LIFDHPTPAL LAEWLRTELA GERTDTGTAP
LRTPHDDEPI AIVGMGCRYP GGVSSPEDLW RLVSEGRDAI SGLPEGRGWD LEHLYDPDPD
AGEGGRTYTR GGGFLHDADL FDAGFFGVPP REAEAMDPQQ RLLLEVSWEA LERAGIRPDT
LKGSATGVFT GVMTSGYRPA PARVPVEFEG HVLTGNESSV ASGRVSYVLG LEGPALSVDT
ACSSSLVALH LAVQSLRRGE CSMALAGGVT VMAAPATLIE FARHRGLSPD GRCRAFGEGA
EGTGFGEGCG VLVLERLSDA RRAGRRVLGV VRGSAVNQDG ASNGLTAPSG RAQVRVVRGA
LEDAGLAAGD VDAVEAHGTG TRLGDPIEAQ ALLSAYGAGR EVPLWLGSVK SNIGHTQAAA
GVAGVMKMVL AMRHGVLPRT LHAEVPSSHV DWSSGGVELL AEAREWPVLD RPRRAGVSSF
GISGTNAHVI VEGVAEEPTT AAGRPVDDVV PWVVSGRSVE ALRAQAGRLA EHLTERPEVG
AGSVGWSLVA QRSLFEQRAV VTGADREELL AGLRTLAEGG TADNVTVTPS TTPPDGSNRL
ALLFTGQGAQ RLGMGRRLHR DFPVFAKAFD EACAQLDAHL PVPLKDVVFG TDADLLDRTL
YAQSALFALE TAQFRLLEHY GIRPDHLLGH SVGEVAAAHV AGVLDLPDAA LMVATRGRLM
QAARGDGAMI AVEATEQEVL TVLGEREDLA GIAAVNGPRS VVVSGDAAVA TEVADHFAAL
GRRTRRLRVS HAFHSPHMDS ALEEFRTVLE GLTFSAPVLS VVSNVTGREA TAEQLCSPDY
WVSHIRRAVR FGDGVEHLAG LGVGTYLELG PDGVLTGLVP DCLPAGTDAV TLPLLRARRP
ESGSLLTAVA QAAFAGHLPD WSPLFPGARP VELPTYAFQH RSYWLTQDTA VADVASAGLE
TVGHPLLGAA VERPDGRGWV FTGRLSPTTH PWTEDHVIGE EVLLPGVALL DVALAAGARA
GCRRLDELTL EAPLSLHPDA PADLRVVLDP EEEGRWSLAV FSRSDDTWRR HATGVLAAGA
EGTGSALTDW PPKDATPLDV ADAYQALAAR GYDYGPTFQG LRAAWRDGDV LYAEVGLPAG
VEPSGFGVHP AVLDAALHLL VLEGDQAAGL RLPFAWSGAE LHATGATALR VRLTPTGTDT
VALAVCDAAG APVATVEALT LRPYSAAGGG RTPLFAVDWV PVPDPAAGTA PAGPAPDLPT
GPPTDRWAVL GTRGPDLPGV ARHADLTMLA GAVEDLEVAV LPWTASAPEH AVPSAAHDAA
REVLGLLKSW LAEEHRTSAP LVVLTRNAVA VEAAEGVADL AASVLWGLLR TAQTEHPGRF
VLLDADADPT PGLVAAALAT GEPQLALRNG TLKAARLARQ TPRELLAPPE GAPAWRMEPG
ASGSLDALSL RPRPEALAPL LPGEVRVAVR AAGLNFRDAL NALGLYPGDA GPLGIEGAGV
VTEVGPGVTG FAPGDRVMGL LPGAFGPVVA TDSRMLVTVP DGWTFAQAAA VPVVFLTAYY
ALTDLAALAP GQSLLVHAAA GGVGMAAVQL AHHLGARVFG TASPGKWDTL RSMGLPDERI
ASSRDLLFEQ GFRRVLGEDG GFDVVLNALA HEYVDASLRL LRPGGRFLEM GKTDVRDPAS
LPDVSYQAFD LMVVDADRIQ EMLTELVRLF EAGALTHLPL TVRDVRRGRE AFRHISQGRH
TGKNVLTLPV SLDPEGAVLV VGGTGVLGAL LARHLVVACG VRHLVLVSRR GVEAPGAVGL
RDELLELGAR TVVVRACDAA DRVALGVLVD EVVAQRPLTG VFHVAGVLRD GVLVSLGAEA
LGEVLRSKVD GAWALHEVTR ERCPGLAAFV LYSSVSGLVG TAGQANYAAA NTFLDALAQE
RSARGLPGLS LAWGLWEQES GMTAGLDDTA FQRFERYGIG KIPSEQGMAL FDEARQGSEP
AVAPLVLDPA RLHARAAVAD LPPLLRGLVS APARRTAAPA AAPRTAGAST WTDRIAGAAG
GRGLDVVTEL LCQEIADVLG HPGPGAIDTG AEFRGLGLDS LTLVELRNRL NAATGLRLPV
NVLFDQPTPD ELAAHLLAAL EPGQPDPVSR ILADADRMEE ALKLFAGERE DRTRVTTRLT
QILRAWQREQ DEPAEPADDL DHVTDDELFD ALDNELSR
//