ID A0A1Q4VZ13_9ACTN Unreviewed; 7364 AA.
AC A0A1Q4VZ13;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Carrier domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMK13_28700 {ECO:0000313|EMBL:OKI03025.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI03025.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKI03025.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKI03025.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI03025.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LIPD01000011; OKI03025.1; -; Genomic_DNA.
DR RefSeq; WP_074004725.1; NZ_LIPD01000011.1.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd19540; LCL_NRPS-like; 5.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 6.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 6.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 6.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186379};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..461
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1718..1793
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3188..3263
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4241..4316
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5269..5344
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5966..6041
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 7019..7094
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1653..1678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3853..3875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7001..7021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4..31
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 7364 AA; 785079 MW; DE56617E5D9CECAF CRC64;
MSNEAKLRDY LKRATADLRE ARQQARELEE KAHEPIAIVG MGCRYPGGVS SPEDLWQLLS
EGRDAISGFP EGRGWNLDGS GAPARDQDAR GPGSIPTRSG GFLHDADLFD AGFFGVSPLE
AEAMDPQQRL LLEVSWEALE RAGIRPDTLK GSATGVFTGL ISGEYVSRLS SVPAEAEGYA
GTGNTASVAS GRVAYVLGLE GPAVSVDTAC SSSLVALHLA VQSLRRGECS MALAGGVTVM
AGPSTLVELG KQGGLSPDGR CRAFGEEADG TGFGEGCGVL VLERLSDARR AGRRVLGVLR
GSAVNQDGAS NGLTAPSGRA QVRVVRGALE DAGLSAGDVD AVEAHGTGTR LGDPIEAQAL
LSAYGAGREV PLWLGSVKSN IGHTQAAAGV AGVMKMVLAM RHGVLPRTLH AEVPSSHVDW
SSGGVELLSE AREWPELDRP RRAGVSSFGI SGTNAHVIVE GVSEEATTSP DGPVDDVVPW
VVSGRSVEAL RAQAGRLAEH LTEHPEVGAG DAGWSLVAQR SLFEQRAVVT GADREELLAG
LSVLAEGGRA DNVTVTPSTT PPDGRRGTVF VFPGQGSQWA GMARELLAGS PAFEEQLRAC
DQALTPYVDW SLLDVLNGRD GAPPLHRVDV VQPALWAVMI GLAAVWRSLG VRPDAVVGHS
QGEIAAAHVA GALSLDDSAK IVAIRSRALL RLAGTGGMVS VAAPVEDVRA LLATIDGHAE
IAAVNGPSST VVSGGPEALD RLTARCEAGG IVSRRIDVDY ASHSASVEPL REQLLAELAG
ITPTTCDTAF YSSVTATALD TARLDADYWY DNLRRPIRFQ EAVQAAADGG HGFVVESSPH
PVLTAGIEET LGGERVVVGS LRRDHGAVRQ ILTNAARLHT GGLPVDWSQL FAGARPVELP
TYAFQRRSYW LKEDTAVADV ASAGLETVGH PLLGAAVERP DGKGWVLTGR LSPTTHPWAA
DVPHAVLLEL ALAAADRAGC DRLERLTVET PLSLGRTATD VQVVVETLGR GRCSLSVFSR
ASGTWIRHAT GELTETPVDA GPAPAATGPD HEVLRADVEL PAHTDPVGYG VHPVLLAAAL
RPFAGTGAPR TWSGVELYAT GATALHVSLT PTGADTARVS AVDAMGEPVL SIGEVTMSQQ
TMAEVEAEVH DDLFHLDWTA LGGHAVRPSA EDSWGVLGSA DGLALPGAVA YPDPAALARA
AEVPGTVILP CLDVEGDGRD VPGAARAVAQ RALEVLQDWL AEGRLARSRL VVLTRGAVAT
APDEGVSALS ASVLWGLLRS AQTEHPNRFV LLDVDTDPDR DTLAAALATG EPQLALRGGT
LLAPRLTRTA PAEFRAPVSL DPEGAVLVVG GTGVLGALLA RHLVVACGVR HLVLVGRRGV
EAPGAVGLRD ELLELGARTV VVRACDAADR VALGVLVDEV VARRPLAGVF HLAGVLRDGV
LVSLGAEALG EVLRSKVDGA WALHEVTRER CPGLAAFVVY SSVSGLIGGA GQANYAAANT
FLDALAQERS ARGLPGLSLA WGLWEQESGM TAGLDEGDLG RIRRSGVLPL PTPRALALLD
LAIRTDRPVM APVRLDSVGL RERSAGPVPS VLRRLVRRPR RIAATGAESF SLAGLLSGGR
EDERGRRLLD RLRDQLLEHP EVSHAIPVLV RAEDPAEQEQ EQEQEQEQEQ EQEQKRTTAR
AETRLVAYVL PGPSPKVLQE LRDRLPAHLA PVEILGADEP HAREAVLCGL FAELLGLTRV
APGDSFFDIG GQSLLATRLI SRVRGVLDAE IQPGELFEHP SPGALALRLG HGTGERRTRL
APVSRPDVLP LSFAQQRLWF QHRLEGPSAT YNVPLALWMS GEPDPAALAA ALNDVVGRHE
SLRTVFEEAD GEPCQRVLAE FEVPLETRRL ETADLRGELT VASRYAFDLA TEVPIRSWLF
STGPSEHVLL VVLHHIAGDG WSMVPLARDL AEAYAARLDG AAPGWEPLPV QYADYTLWQR
DLLGGADDPD SLFGRQVDYW RQELADLPTE VSAPADRARP AVASYAGDVT PFALDPDLHR
ALSELARAHD ATVFMVLQAA LAALLTRLGA GTDIPLGSGI AGRTDEALDR LVGFFVNMLV
LRTDTSGDPS FAELVTRVRE TSLAAYAHQD VPFESLVEEI NPHRSTAHHP LFQVALTLQN
NEQARFRMSG LDVRPELVGT GTSRFDLFFS LTESHGANGE PAGIDAYVEY ATELFDASTV
DALIHRWTAF MRALVSDPAA PIGAADILTP REHARITGWN AGPTRDTTGS SLPALFAAQA
ARTPDATALV CEDVELTYRE LDARANRIAH WLRARGIGAE QHVAVLYERS PEQIAAVLGV
LKAGAAYVPL DPEYLAERVG HILADAAPEL ILTTRALADT IGTLHDGTET VATDDPGTAA
ALAGCPDHDP EPAAPPHPGH PAYVIHTSGS TGVPKGVVVT HQGLGSLAST LLRQCAVTPD
SRVLQLSSPG FDAAVLELTM AFAAGAALVL GGRDRLVGAE LADVLADRRI THALVPPSVL
GTLPAGSAEA LTGFRTLIVG AEACGADLVR TWSPGRRMVN AYGPTESTVV AAISEPLTGG
DVPIGRPVDN TRVRVLDERL RPVPPGVPGE LYLAGAGLAR GYLDRPGLSA QRFVADPFGP
AGTRMYRTGD VVRWTAEGQL EYLGRADQQV KVRGFRIEPG EIEAVLREQS GVAQAVVVVR
EDREGDPRLV AYIVPEGEGA EDDQVDEWRE IYDDVYGGAG TETPGFGQDF TGWNSSYTGE
PIPLDEMRDW RDAAVRRITE RPPRRVLEIG VGSGLLFGPL APRAETYWAT DFSAPVIERL
TAQCETAGLA DRVRLLCRPA DVVDDIPAEY FDTVVLNSII QYFPDADYLA RVLDGALGRL
APGGRIVVGD VRHRGSLRAF QTGIHLGHAA EDGTGEQLRA AVEHAVIMEK ELVIDPDFFT
VWARRHPEAV AGVDIRLKRG AHHNELTRHR YEVVLHKADG TARAESLADV PELVWGRDLT
SLQDLAGLDA LTSGAGPVRV TGLVNSRLTG EVAAAEELAH EASPQRLRAR LSTGRADGNA
PEAVDPEALH EWGERHGCQV LTTWAPGAPD ALDAVLVPGG RADAVYTDVH RPAYTQDKPL
SALVNNPLGS RTTGRVLAGL RDALRQRLPE YMVPSAVIAL DALPLTSSGK LDRRALPAPD
YASRSARGPR TPREEILCGL FAEVLGVDRA GIDDDFFDLG GHSLLATRLV SRVRSVLGAE
LPLRAVFETP TVAGLVERLS SGGAVRPELV AGERPERLPL SFAQQRLWFL HRLEGPSATY
NMPLALRLSG VLDRGALAAA LDDVVGRHES LRTVFAEVDG ASYQRVLTGV RVPFEVSEVE
PAALDAALAG AARYAFDLAA ELPIRSWLFG TGPSEHVLLV VLHHIAGDGW SMAPLARDLA
EAYAARLEGA APGWEPLPVQ YADYTLWQRE LLDGVREDEL TYWRGQLAGL PEEVSPPADR
ARPAVASYAG ETASFGLSPA LHRAVGEVAR AHDATVFMVL QAALAVLLSR LGAGEDVPIG
SPVAGRSDEA LDDLVGFFVN TLVLRTDVSG DPSFAELVGR VREAGLGALA HQDVPFEYLV
EELNPRRSAA RHPLFQVMLA LQNTEQARFE LPGLEVAAEP VGTGVSRVDL TLSLAEDPDG
GMRGVAEFAT DLFDRSTVEV LLDRWVRLLE GLTARPELPV AQVDILTPEE RRQLLSGRND
TDLPVRSLVT AFRAQVERVP DAVAVVADGT RLTYAQLDER ADRLAHELIG RGVGAERLVA
IAMPRSIGFV VAVLAVVKAG GMYLSLDARY PESQVRRMWA DNDVNLLLTD SPTRVPAFVP
GDQVLLVQDD AAHVPSTSTS PSAPSTPPAG DRGAAPDPDQ LACVIYTSGS TGTPKGIGLT
HADITSLADD PVVGGYPARV LLHSPTAWDA LPFELWMPLL LGGRVVIAPD VPLDGPHLRD
IVRDHGITSM WITAGLFKAM AEDHPDCFAS MRQVFTGGEV VPQGPVRRVM AACPDLTVVN
GYGPGETTTF ATLHAMAPGH DPEPSLPIGR PVTGKQVYVL DERLGLVPPG VVGELYVAGA
GMARGYLGQP GLSAQRFVAD PYGPAGTRMY RTGDLARWNR DGLLEFAGRA DHQVKIRGFR
IEPGEVESGL RRCAGVAHAT VVVHTVREGD VRLVAYVVTE PGTGFDPSAI AGELRGRLPE
YMVPALITAV PAIPLTPNGK VDRAALPAPD FGALVSEGGR GPRSAREAAL CEVFAEVLGV
ERVGIDDDFF DLGGHSLLVM RLMSRVRERL AAELPLRAVF ESPTVAGLVE RLASGAVARP
ELVAGVRPER LPLSFAQQRL WFLHRLEGPS ATYNMPLGLR LSGVLDRGAL AAALDDVVGR
HESLRTVFEE VDGEPCQRVL TGVRVPFEVS EVEPGGLGGA LAGAARYAFD LSVELPIRAW
LFSTGPSEHV LLIVLHHIAG DGWSMAPLAR DLAEAYAARL EGVAPGWEPL PVQYADYTLW
QREVLDEVRD DQITYWRGQL AELPQEVSLA ADRVRPAVAS YTGDVTTFAL DPDLHRALGE
LARSSNATLF MVLQAALAVL LSRLGAGEDV PIGSPVAGRS DEALDDLVGF FVNTLVLRTD
VSGDPSFAEL VGRVREAGLG ALAHQDVPFE YLVEELNPRR SAARHPLFQV MLALQNTEQA
RFELPGLEVA EEPVGTGVSR MDLTLSLAEE PGGGMRGIAE FATDLFDRST VEGFLGRWVR
LLEGLAARPE LPVGQVDILT PEERHQLLSG WNDTGRDVPA TTVPELFAAQ AARTPEAEAL
VAGAARLSYA QLNARANRIA HWLLAQGVRP GDTVAVALPR SVELVAVLLA THKAGAAYLP
LDLDYPAERT AFMCRDAEPA YVVDDLDLIS GLLDGDGGDA TDPAVEQHPG LPAYVIYTSG
STGRPKGVVV PQRAIVNRLL WMQDEYGLGP DDRVLQKTPS SFDVSVWEFF WPLVTGATLV
VAEPGGHRDP AYLSRLIQTE AVTTVHFVPS MLEAFLADES TARCTGLTRV MCSGEALPAD
LAARFHDTLP HAELHNLYGP TEAAVDVSSW HSVADPGVVP IGRPVWNTRL YVLDAALRPV
APGAPGELYI AGVQLADGYL RRPGVTAERF VANPFGAPGD RMYRTGDLAR WTADGVLQFL
GRADQQVKIR GFRIEPAEIE AALTSHPAVR QALVVARENA LVAYAVPEEG AGIDTRQLRE
HLRATLPDHM IPAAVVPLDR LPLTPSGKVD RAALPVPDFG GSVSEGGRGP RSAREAALCE
VFAEVLGVDR AGIDDDFFDL GGHSLLATRL VSRVRSVLGA ELPLRAVFES PTVAGLVERL
ASGAVVRPEL VAGERPERLP LSFAQQRLWF LHRLEGPSAT YNMPLAMRLS GALDRGALAA
ALDDVVGRHE SLRTVFAEVD GEPCQRVLTG VRVPFSVSEV EPAVLRRELD EAARYAFDLS
TELPIRSWLF GTGPSEHVLL VVLHHIAGDG WSMAPLARDL AEAYAARLEG AAPGWEPLPV
QYADYTLWQR EVLDDVLDGQ IAYWSGQLAD LPEEVSPPAD RARPAVASYA GDMTSFVLDP
DLYCAVGEVA RAHDATVFMV LQAALAVLLS RLGAGEDVPI GSPVAGRSDE ALDDLVGFFV
NTLVLRTDVS GDPSFAELVG RVREAGLGAL AHQDVPFEYL VEELNPRRSA ARHPLFQVML
ALQNTEQARF ELPGLEVAEE PVGTGVSRVD LTLSLAEEPG GGMRGVAEFA TDLFDRSTVE
VLLDRWVRLL EALTARPELP VGQADILTSD EYRELSRLDY VLDRNLRLVP RGVVGELYAR
GAESDLAGSD PERWVPDPFG APDARMYRTG DLARRRTDDG HLELVGPADP LAAALEIEAV
LRTLPGVAEA AVVVDGEATR SVAYVVPLVM NQFSVSRLHE DLKHRLPEHR LPAVVMPVPA
LPLTADGALD RAALPGPDHV PRAVRTTRSP QEEILCGLFA EVLGVDRVGI DDGFFGLGGH
SLMAARLVSR VRSVLGVELP LRAVFESSTV AGLAERLSSG GVVRPELVAG VRPERLPLSF
AQQRLWFLHR LEGPSATYNM PLGLRLSGAL DRGALAAALD DVVGRHESLR TVFAEVDGES
CQRVLAEAPV PLVTVEVDAD GLRDAMAEAA RYAFDLAAEI PLRAWLFASG PSEHVLLVVL
HHIAGDGWSL APLARDLAEA YTARLEGSAP GWEPLPVQYA DYTLWQREVL DEVRDDQIAY
WRGQLAELPE EVSLPADRAR PAVASYAGGT ASFELGPDLH RALGELARSS NATLFMVLQA
GLAVLLSRLG AGEDVPIGSP VAGRSDGSLD DLVGFFVNTL VLRTDVSGDP SFAELVGRVR
EAGLGAFAHQ DVPFEYLVEE LNPRRSAARH PLFQVMLALQ NTEQARFELP GLEVAEEPVG
TGVSRVDLTL SLVEEPGGGV RGVAEFATDL FDRSTVEGFL DRWVRLLEGL TARPELPVAQ
VDILTPEERH QLLSGWNDTG RDVPATTVPE LFAAQAARTP EAEALVAGAA RLSYAQLNAR
ANRIAHWLLA RGIRPGDTVA LMYERSADLV AALLGVLKTG AAYLPVDPEF PSARVAHILT
EAAPALLLTS DAVATGAGAG ALAERPSSAT VVTDAPDTAA ALALCPDTDP APVAGAADPA
YVLYTSGSTG APKGVVVEHG ALSNFLADMA ARFPLTTGDR WLGVTTVGFD ISVLELCLPL
TSGATLVLAD RDTARTPAAL AGLLRATGAT VMQATPTLWR ALADEQPGCL DGLRVLVGGE
ALPPDLARTL AARAAEVVNL YGPTETTIWS TAAGIAPGAA PERTPIGTPI ANTRVHVLDE
RLGLVPPGVV GELYIAGAGV ARGYLGQPGL SAQRFVADPY GPAGTRMYRT GDLVRRNRDG
LLEFAGRADQ QVKIRGFRIE PGEIEVLLRE QPGVAHAVAV VREDRPGDQR LVAYVVPDEP
ADAPHLAERR DLRDALHLRL PEYMVPSAVL TLPALPLTPN GKLDRRALPA PDRGAAGRGP
ASPQEAVLAG LFAEVLGVER VGVDDGFFDL GGHSLLATRL IDRVRDVLGV ELPLRALFET
SDVAGLARRL DADHDGSADA FGVVLPLRPR AEGVPLFCVH PGGGLSWSYA GLLRHLPAEV
PVYGIQARGL SEPDDLPGSV EEIADDYIAE LLRLRPEGPF PLLGWSFGGV VAHAMAARLR
ERGFDVPFLV LLDAQPARPR TAEELAEEAT LDTSMVYRTL LTAFGVPVGD GEPLTHARFT
ELAREHHAAV ADFTEDRIAD VLRVMANDLR ITPAHRHTPV ATEAVVFAAT RKDPSDLVTP
EMWAPYIDGP LDHRTVDCGH AAMAGPEALR VIGPILAERM RRLS
//
