ID A0A1Q4W4C1_9ACTN Unreviewed; 381 AA.
AC A0A1Q4W4C1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=D-galactonate dehydratase {ECO:0000313|EMBL:OKI04913.1};
GN ORFNames=A6A06_09450 {ECO:0000313|EMBL:OKI04913.1};
OS Streptomyces sp. CB02923.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI04913.1, ECO:0000313|Proteomes:UP000185893};
RN [1] {ECO:0000313|EMBL:OKI04913.1, ECO:0000313|Proteomes:UP000185893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02923 {ECO:0000313|EMBL:OKI04913.1,
RC ECO:0000313|Proteomes:UP000185893};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI04913.1}.
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DR EMBL; LWKZ01000012; OKI04913.1; -; Genomic_DNA.
DR RefSeq; WP_073761677.1; NZ_LWKZ01000012.1.
DR AlphaFoldDB; A0A1Q4W4C1; -.
DR STRING; 1718985.A6A06_09450; -.
DR OrthoDB; 9802699at2; -.
DR Proteomes; UP000185893; Unassembled WGS sequence.
DR GO; GO:0008869; F:galactonate dehydratase activity; IEA:InterPro.
DR GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR GO; GO:0034194; P:D-galactonate catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR034593; DgoD-like.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR023592; Galactonate_deHydtase.
DR InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR PANTHER; PTHR48080:SF2; D-GALACTONATE DEHYDRATASE; 1.
DR PANTHER; PTHR48080; D-GALACTONATE DEHYDRATASE-RELATED; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDF00003; D-galactonate_dehydratase; 1.
DR SFLD; SFLDG00179; mandelate_racemase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR PROSITE; PS00908; MR_MLE_1; 1.
DR PROSITE; PS00909; MR_MLE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000185893}.
FT DOMAIN 125..230
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 381 AA; 41776 MW; CC1C7DB30372A44D CRC64;
MKISRVETFL APPRWMFVRV ETDEGLVGWG EPVVEGRAEP VRAAVEVLSE YLIGQDPSRI
EDHWQVMTKG GFYRGGPVLS SAVAGLDQAL WDIKGKELGV PVHQLLGGPV RERVRAYAWV
GGDEPDEIRD ALTAQVEAGF TAVKMNGCGR MTPVATRAEV RDCLRRAETA RAVLGDDRDF
GLDFHGRVSP ANARRLLPLL AEHAPMFVEE PVLCDYPHAL PDLVNASNIP LALGERLFTR
QEFLAPLQAG VAILQPDISH AGGISELRRI AALAETYGAQ LAPHCPLGPV ALAASLQVAF
TTPNFLIQEQ SIGIHYNQGA ELLDYVADPE PFRFHEGSFL RTDRPGLGVT VDEPAVRAVD
RQGHAWRNPV WRHADGSFAE W
//
