ID A0A1Q4W5Z5_9ACTN Unreviewed; 351 AA.
AC A0A1Q4W5Z5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=NAD-dependent dehydratase {ECO:0000313|EMBL:OKI05503.1};
GN ORFNames=AMK13_19175 {ECO:0000313|EMBL:OKI05503.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI05503.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKI05503.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKI05503.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI05503.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LIPD01000007; OKI05503.1; -; Genomic_DNA.
DR RefSeq; WP_074003352.1; NZ_LIPD01000007.1.
DR AlphaFoldDB; A0A1Q4W5Z5; -.
DR OrthoDB; 9801785at2; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF49; HREPIB; 1.
DR Pfam; PF01370; Epimerase; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186379}.
FT DOMAIN 3..129
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 169..281
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 351 AA; 36574 MW; 65916BA0649B7D2D CRC64;
MRILVTGGAG FIGASVVRAL VAAGHHVRVL DALLPAVHPT GNPPALPAGV DFRRGDVRDA
ATVEEALAGV DAVCHQAAMV GLGLDLQDAP HYVGCNDLGT AVVLAAMART GVRRLVLAGS
MVVYGEGRYH CAEHGEVAPG PRRPADLDAG RFEPPCPVCG APLRPGLVAE SAPADPRSVY
AVTKLAQEHL SAAWARACGG TVLTLRYHNV YGPGMPRDTP YAGVASLFRS ALARGEAPRV
FEDGRQRRDF VHVEDVAAAN LAALAAVGDR PPGSVRAYNV GSGEVRTIGE MAAALAAAHG
GPAPTVTGEY RLGDVRHVTA DSNRLRAELD WLPRVPFDRG MAEFAAAPLR V
//
