ID   A0A1Q4W667_9ACTN        Unreviewed;       902 AA.
AC   A0A1Q4W667;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Bacterial transcriptional activator domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AMK13_19675 {ECO:0000313|EMBL:OKI05576.1};
OS   Streptomyces sp. CB02056.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI05576.1, ECO:0000313|Proteomes:UP000186379};
RN   [1] {ECO:0000313|EMBL:OKI05576.1, ECO:0000313|Proteomes:UP000186379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02056 {ECO:0000313|EMBL:OKI05576.1,
RC   ECO:0000313|Proteomes:UP000186379};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKI05576.1}.
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DR   EMBL; LIPD01000007; OKI05576.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q4W667; -.
DR   OrthoDB; 4336084at2; -.
DR   Proteomes; UP000186379; Unassembled WGS sequence.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF03704; BTAD; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186379};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          1..135
FT                   /note="Bacterial transcriptional activator"
FT                   /evidence="ECO:0000259|SMART:SM01043"
FT   DOMAIN          444..677
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          148..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..179
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   902 AA;  95490 MW;  38A479F6883D0F0E CRC64;
     MGRARLAAGD WTRASELLRR ALGLWRGPVL ADVSDAGLTW PELAALQGTR LAVHEDCIQA
     ELAMGRDREL IGELESMLEA EPTRERLVAQ LMVVLYNCGR QSEALDRYRR TRDLLADRFG
     LEPGRDLRRL QRAILSHDPA LALRLTTAPG GAADFPPPAG PRPAAAAAPQ PPRPRPAPTP
     PARADDRADG SRADDSGAGR AGTAAAPAAE HAFRASWERV ERRAASVVMV RAQWTADGGA
     LAPERVDHAV KELTADIRRE MAPFGGHVRR AFGSVWLVVF GVPRAHEDDA ERALRAALAL
     HRHFEAPGPA TPGATAAGPV PGSGAAATRP VTHLVVGTGE VVVTYDDSAP EPVEVTGEVL
     DACHHLLLQV PRGELWAADA TVETGGADLG FAPVPGVPGV HRPAPARPEG RGPSGHPAEP
     PFLERTHELN LLRGAYQDSV RRQLPYLVTV LGEPGIGKTR LIGEFAAALR DGAGPPAPRV
     LHAGTPAFDA HTPYEPLAGL VRAYTGIRAG APAAVVLPAL TNVVRGLLPH ADTGPIVTAL
     AACLGLPAPA ASAEGPDGGA VPREEVLGAL RQFLEEAAAE RPLVVVLDDL HRAADFVRSF
     VEDLTVRLGP VALLLIVGAR SELLHTRPSW GCAKRRSVLL HVAPLSTAAT ATVIGAASGR
     RHPTPADDRR AALADGNPLF AQAYARAADA GADHPPAVLA VAAAQLDGLD RTTRSVLRDA
     AVVGGTLWRG AVEAVSQRDP EEVGRSLELL ESRELLRRVR RSGVPGDVEY AFRYAVSRDV
     ALAQLPGRVL VERHLRAADW AALLDVPRPG LLAFHHDRAI ALAEADGTPV EAMERRAWEA
     LVGASARAAA AGDDALAVSC LDHALDRCPP GEPERVWLVT HHRRIRDSLG ARVHRRRPAV
     TG
//