ID A0A1Q4W8Q5_9ACTN Unreviewed; 1020 AA.
AC A0A1Q4W8Q5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:OKI06493.1};
GN ORFNames=AMK13_18160 {ECO:0000313|EMBL:OKI06493.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI06493.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKI06493.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKI06493.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI06493.1}.
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DR EMBL; LIPD01000006; OKI06493.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4W8Q5; -.
DR OrthoDB; 3501794at2; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186379}.
FT DOMAIN 501..576
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1020 AA; 107249 MW; 46D5904A8255B6DD CRC64;
MSARPASVPL TLPALLDHRA ALHPERTALL VPGGGSLTYG RWRERAVRAA HGLAGAGVRP
GDTVALLFTN REWDAYAVAF LAAHYAGAAG LVIREDLAPA DVERLVEAAG ARWAVAGSGP
RTALPTFALD GLDGLGGLDT PDEPPHRVAP GDLAQVIGTS GTTGTPKGVR AAHASLTAGL
VLDPRPRPYA HSRHAVHAFP IGTNAAQAVL VNALTAQPTT ICLPRFDAEE FGRVVEESGA
GTVFLVPSMA VELLNSGVAD RRDLGSVRLV GSTAAALPPA VAAGLSAALP KATVVNTYTS
AEAAPAQISA VVDPGRPGSL GRPTDPADLR ILDEAGEPVP TGGTGEIWLR QPGPPRGYAG
AASDTVFRDG WVRMGDLGRL DGDGYLHLVD RESDIVKSGA LKVSTLRIEA VLHEHPQVAD
AAALGLPHPV MGQVPVAAVV PRPDGIDLDG LRLFLSERLA RPELPVRVLV LDSLPRNPSG
KVLKHELRAA FEEPAPTTGR APETERELAL AGLWRAVLGR PVRAVEEEFF ALGGDSFRAV
QLAAAISAEF GVAARTALVF ERPSLRAQAA WLERADVAPA EPAERSGAEV SDFLRSLRAQ
PHDLPLTSQQ ENFLRWMAEA PGRNVGAVAV MFRVTEGLRT DVLADALHEA IRRHPALRTR
FVPVPGAEPG VLRAVLDDEP HADVVLVEAP GASDDEVSAR LVAVRDRLTD VAAGPMTRLA
VVSRGPADHV VLLAVHHLVS DGWSLGVLLR ELGVAYSALC HGRRVPAARP GPEYGELVEW
SNAHWPASRT HFGTALAHAP AAIDPFPGRR HTEVVLSAAH AFTVPPAAAD ALRARAAELG
ATPFLAVAAV WSGLLAARSG QPDLVLMTPV PGRTRPEAER AVGCFVQSLL VRVDVSGAPG
FAELLDRVRS AATTALDHQL YPFAEFSPLV PFAAWLRYEN WSAPAQLPGV ACAAWELPRN
ATVPYPLPGG DRHVPELAVT EQPDGALRCW LRYNEHAFEA ATVSALADDL AAALAGAAGI
//