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Database: UniProt
Entry: A0A1Q4WBT7_9ACTN
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ID   A0A1Q4WBT7_9ACTN        Unreviewed;       289 AA.
AC   A0A1Q4WBT7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   28-FEB-2018, entry version 6.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:OKI07556.1};
GN   ORFNames=AMK13_13290 {ECO:0000313|EMBL:OKI07556.1};
OS   Streptomyces sp. CB02056.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI07556.1, ECO:0000313|Proteomes:UP000186379};
RN   [1] {ECO:0000313|EMBL:OKI07556.1, ECO:0000313|Proteomes:UP000186379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02056 {ECO:0000313|EMBL:OKI07556.1,
RC   ECO:0000313|Proteomes:UP000186379};
RX   PubMed=27999165;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural
RT   Products.";
RL   MBio 7:e02104-16(2016).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OKI07556.1}.
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DR   EMBL; LIPD01000004; OKI07556.1; -; Genomic_DNA.
DR   RefSeq; WP_074002349.1; NZ_LIPD01000004.1.
DR   Proteomes; UP000186379; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000186379};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186379}.
FT   DOMAIN        7    186       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      189    285       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   SITE        142    142       Important for catalytic activity.
FT                                {ECO:0000256|PIRSR:PIRSR000105-1}.
SQ   SEQUENCE   289 AA;  31123 MW;  2712E518DE44D81C CRC64;
     MSDIARVGVI GCGLMGSGIA EVFARAGLDV LVSEASGEAL EFGRTRLTNS LETAVKRGKL
     SPEQRDEALA RLSFTVELSD FADRDLVVEA VAEREDIKVK IFETLDRVVE RRDAILASNT
     SSIPIVKLAA ATTRPEQVIG LHFFNPAPVQ KLVEVIPTLT TSATTTERVE AFASQVLGKE
     PIRARDRAGF VVNALLVPYL LSAVRMFETG VATASDIDKG MEAGCAHPMG PLRLCDLIGL
     DTIVSIAESM YDEYKEPLYA APPLLSRMVD AGLLGRKSGR GFYDYTASA
//
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