UniProt: A0A1Q4WDI5

Database: UniProt
Entry: A0A1Q4WDI5_9ACTN

LinkDB:  A0A1Q4WDI5_9ACTN 
Original site:  A0A1Q4WDI5_9ACTN

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Ontology (9)   
   GO (9)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (24)   
   InterPro (14)   
   Pfam (5)   
   PROSITE (3)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (36)   

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ID   A0A1Q4WDI5_9ACTN        Unreviewed;      3448 AA.
AC   A0A1Q4WDI5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN   ORFNames=A6A06_35120 {ECO:0000313|EMBL:OKI08085.1};
OS   Streptomyces sp. CB02923.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI08085.1, ECO:0000313|Proteomes:UP000185893};
RN   [1] {ECO:0000313|EMBL:OKI08085.1, ECO:0000313|Proteomes:UP000185893}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02923 {ECO:0000313|EMBL:OKI08085.1,
RC   ECO:0000313|Proteomes:UP000185893};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKI08085.1}.
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DR   EMBL; LWKZ01000003; OKI08085.1; -; Genomic_DNA.
DR   RefSeq; WP_073760499.1; NZ_LWKZ01000003.1.
DR   STRING; 1718985.A6A06_35120; -.
DR   OrthoDB; 2472181at2; -.
DR   Proteomes; UP000185893; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 2.
DR   CDD; cd17652; A_NRPS_CmdD_like; 1.
DR   CDD; cd19543; DCL_NRPS; 1.
DR   CDD; cd19540; LCL_NRPS-like; 2.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.40.50.980; -; 6.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 3.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 3.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000185893}.
FT   DOMAIN          972..1047
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2032..2107
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3096..3171
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3448 AA;  369512 MW;  817CF182FA04F0AB CRC64;
     MKTQSALEDV LPLAPLQEGL LFHSLYDGQA PDIYNVQLIL RIEGEVDAAA LRASAGTLLA
     RHANLRAGFR TRKNGQPIQV IHRAVPLPWR EHDLTGYADG PAGQDAELER LLATDRAERF
     DLARPPLLRL TLYRLADRRY CLALTCHHVL LDGWSTPLVL SELFTLYGQR GSDAGMPRVT
     PYRDYLAWLG RQDQAAAEDA WQRALAGLEE PTLVAATDRT PEVPGRVALE LPREDTARLT
     AAVRERRLTM STLLNGAWAV ALAQLTGRDD VVFGTTVSTR PADLPGSESM VGLFVNTVPV
     RVRLDQRQPL LDNLVRLQEE QSALLPHQYL GLGRIQQLAD VGDLFDTAAL LENYPLGIAD
     DEDVVAGLRL TEVDGRDATH YALNLVGELV GDRLALRLDH RADVMDRERA TALLGRVRAL
     LASVLDTPDI PLDRIALIGA AEREQVLGTW NDTAHPLPET HPAAMFEAQA ARTPQATAVV
     DDGGSWTYAE LNERANRLAH LLIGRGAGPE QLVALALPRS ADLLVALLGV CKSGAAYLPL
     DPGQPRERIA STLGDAAPST LITAAGTAGA VAGTAVPQLV LDSPGTRAAL AAQPATDPSD
     ADRVAPLLPS HPAYALYTSG STGRPKGVLT TCAGVSGHLA WMASRYPLEP EDRVLFRTAV
     SFDASVWEIW LPLLTGAGLC VAPDDVVKDP ERLMAFIARH RVTVAQFVPS LLAELLRVPV
     DAAPPLEHVF VGGEPIGSGQ AAAAVAAWGV RVHNLYGPTE TTVQVTAHDF DPAADTGTVP
     IGQPVWNTRL YVLDAALRPA PVGVAGELYV AGAQLARGYL NRPGLTAQRF VAHPYGAAGE
     RLYRTGDVVR RRADGRLEYL ERADDQVKIR GQRIEPGEVE SVLAGDPRVG RAAVVVREDR
     PGDRRLVAYL VPAGEGEPDV ASVRARAAEA LPGYAVPAAF VVLDKLPLTA NAKLDRRALP
     APEFGAAAGS RRPRDPREEI LCRLFESVLG VQRVGIDDAF FDLGGHSLLA MRLISRVRAV
     LGVEPAVRDL FEAPTVARLA ARLDGVAGAR PALTRAAERP ERVPLSFAQR RLWFLHQFEG
     PSATYNVPVA LRLTGALDVT ALRTALADLA ERHESLRTVF PEAHGTPYQQ VLGSTAARPV
     LETADVDADR LDAEVREALA RPFDLTGEMP LRAHVFTLAE DDHLLLLVAH HIASDGASAG
     PLLRDLSTAY GARCAGRAPA WAPLPVQYAD YTLWQRDVLG DENDPGSVLA GQIAYWKDTL
     AGLPDQLELP TDRPRPAIAG HQGASVAFQW DADLHTGLVR LAREHQASLF MVVQAGIAAL
     LTRLGAGTDI PIGSPIAGRT DDALEDLVGF FVNTLVLRTD TSGDPTFAEL LARVRETDLA
     AYAHQDVPFE RLVEILNPTR SLSHHPLFQV ILTFQNSEEI EADLPGAEAR DHILSAVAAK
     FDLSFTVEEQ LTGDGTPAGL RGSVEFAADL FEPDTARRIA ERLERLLRAV ATDVTRPIGE
     LELLASEERE QLLTGWNDTA HHVPAATLPE LFQAQVARTP DAVAVVHDRE QLSYAELNAR
     ANRLAHHLIG RGVGPERIVA LALPRSVDLV VAILAVLKTG AAYLPVDPDY PADRITYMLG
     DARPVLVLSD AETARTLPRT EIPVLDVPGT AGTSAGLPER DPVDADRPVP AGVTNPAFVI
     YTSGSTGRPK GVVVEHRSLN IYLAWARSAY GAVGGRALVH SPVSFDLTVT GLFGPLTAGG
     CVQLIELTEE SADELPERPT FVKATPSHLG LLLALPERFS PTGQLVLGGE SLLGEVLDEW
     RQRHPGVTVV NEYGPTETTV GCTEFRIAPG AEAPSGVVTI GRPVWNSQMY VLDARLRPVP
     AGVTGELYIA GELLARGYLN RPGQTAGRFV ANPFAPSGAR MYRTGDLVKW RADGQLEFVS
     RVDNQVKVRG YRIELGEIEA VVAAHPSVGP SAVIVREDRP GDKRITAYVT PADGHRTVDT
     AQLRAHAEEV LPGYMLPSAF VVLDTLPLTP NGKLDHAALP APEAAAAPDG RGPRTAQEEV
     LCDIFAEVLG VERVGIDDNF FDLGGHSLLA MRLISRIRTT FDIELTVRDL FEAPTVAGVA
     VRQADTPQGN SGPAPMDRPE RIPLSFAQRR LWFLHQLEGP SPTYNVPLLL RLTGTLDVPA
     LRAALADLTG RHESLRTVFP HEEGIPYQVI RHGAAGAPTI ECVRPAPDEL ASAITEAVRY
     AFDMTREIPL RAWLFETGPE EHTLLLLIHH IAGDGASVGP LARDLSTAYG ARCVGRAPAW
     APLPVQYADY TLWQRDVLGD ENDPGSVLAG QIAYWKDTLA GLPDQLELPT DRPRPAIAGH
     QGGTVEFAWD TALHQDIARL AREHRASVFM VLQAAVATLL TRHGAGTDIP LGTATAGRAD
     EALDDLVGFF VNTLVLRTHT SGDPTFAELL ERVREADLAA YAHQDVPFER LVEIVNPLRT
     LARHPLFQVA VGLEETAGAA LEMPGLTIEH LPDGMGVAKV DLAFNFAERA GDDGKPDGLR
     GVVEFATDLF EPETARAFAE RLERLLRAAV ADAARPIGEL DMLGAEERER LLTGWNDTAY
     DVPAATFPEL FQAQVARDPG APALEFADVT LSYAELNARA NRLAHHLIGR GVGPERIVAL
     VLPRSVDLVV AILAVLKTGA AYLPVDPDYP ADRIAHMLTD TRPALILTGD GAAGGLPRTG
     VPVLPVAALA PGDDHDPSDA DRTTGLLPDH PAYVIYTSGS TGRPKGVVVA HRGLANLSAH
     QTERLGAGPG SRISQLVSPS FDVSVAELSM GLLAGACLVM PAEQPTGEEL ADFLAGRGIT
     HAHVPPALLT GMPRRELPRL ASLMVGAEAC PPDVIAYWSR GRRMVNAYGP TEATVDSCYA
     FCGPHQGPGR TPIGRPVFNT RLHVLDDLLR PVPVGVTGEL YIAGRGLARG YLGRPGLTAG
     RFVADPYSGT GERMYRTGDL VRRRHDGQLE FVGRVDGQVK VRGFRIELGE IENVLLEHPA
     VGRAAVIVLE GRPGDKRITA YVVPARAGTA PAGAPGAGAG GLDIAELREW VAGVLPEYML
     PSAFVVLDAL PLTPNAKLDR SALPAPRVTG AEGGRGPRTA REEALCALFA EVLGVERVGI
     DDNFFDLGGH SLLAARFVGR VRAMYGVDFR VRDLFAAPDV AAIAGRLDTG RDGSGPGSAA
     APGNGLDVLL PLRTTGDRTP LFCAPPTVPL SWCYTGLLKE LGPDCPLYGL QSPGLDGTGE
     LPRDFAQMIE EYATRIQQVQ PAGPYRLLGY SLGGNIAQAL ATHLQERGEE VELVAVLDAY
     PGGDVEPVPL TDAQTLARFH TDLCGDGGGA KDPARKRTEV IDSLRPGLPG DMTEEQLSRL
     LDAMIAAVGN TSRYEPRVYK GDLLLFTTTV GRPDHDAMPA AWQPLTDGEV VSHLVPATHE
     SLLEGGALST VGALLSEQLR ALDAARGR
//

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