ID A0A1Q4WHA9_9ACTN Unreviewed; 246 AA.
AC A0A1Q4WHA9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=TetR family transcriptional regulator {ECO:0000313|EMBL:OKI09498.1};
GN ORFNames=A6A06_02060 {ECO:0000313|EMBL:OKI09498.1};
OS Streptomyces sp. CB02923.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI09498.1, ECO:0000313|Proteomes:UP000185893};
RN [1] {ECO:0000313|EMBL:OKI09498.1, ECO:0000313|Proteomes:UP000185893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02923 {ECO:0000313|EMBL:OKI09498.1,
RC ECO:0000313|Proteomes:UP000185893};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI09498.1}.
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DR EMBL; LWKZ01000001; OKI09498.1; -; Genomic_DNA.
DR RefSeq; WP_073758178.1; NZ_LWKZ01000001.1.
DR AlphaFoldDB; A0A1Q4WHA9; -.
DR STRING; 1718985.A6A06_02060; -.
DR OrthoDB; 8479950at2; -.
DR Proteomes; UP000185893; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF174; TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)-RELATED; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000185893};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 21..81
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 44..63
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 246 AA; 26577 MW; 125C92C3509A1CB2 CRC64;
MNGSGTAPAV PRPAYRRLSV EQRRSQLLSA ALGLFAQRAP EDVSLDDVAA AAQVSRPLVY
RYFPGGKQQL YEAALRSAAD ILEGCFDEPE DGPLTQRLGR ALDRYLAFVD GHDAGFSALL
QGGSVVETAR TSAIVDEVRR TAAEQILHHL GADAPSPRLR MAVRTWITAV EAASLIWLDE
DKQPPLDELR DWLVDHFVAL LTATAATDEQ AARAARAALE RETAEGPVGV LARRILPIVA
DAAHLL
//
