ID A0A1Q4WIZ6_9ACTN Unreviewed; 547 AA.
AC A0A1Q4WIZ6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=A6A06_05420 {ECO:0000313|EMBL:OKI10050.1};
OS Streptomyces sp. CB02923.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718985 {ECO:0000313|EMBL:OKI10050.1, ECO:0000313|Proteomes:UP000185893};
RN [1] {ECO:0000313|EMBL:OKI10050.1, ECO:0000313|Proteomes:UP000185893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02923 {ECO:0000313|EMBL:OKI10050.1,
RC ECO:0000313|Proteomes:UP000185893};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI10050.1}.
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DR EMBL; LWKZ01000001; OKI10050.1; -; Genomic_DNA.
DR RefSeq; WP_073759285.1; NZ_LWKZ01000001.1.
DR AlphaFoldDB; A0A1Q4WIZ6; -.
DR STRING; 1718985.A6A06_05420; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000185893; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:OKI10050.1};
KW Helicase {ECO:0000313|EMBL:OKI10050.1};
KW Hydrolase {ECO:0000313|EMBL:OKI10050.1};
KW Nucleotide-binding {ECO:0000313|EMBL:OKI10050.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185893}.
FT DOMAIN 189..343
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 397..547
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 547 AA; 60772 MW; A82C84C757D9B254 CRC64;
MNGPLIVQSD KTLLLEVDHE QAEACRRAIA PFAELERAPE HMHTYRVTPL GLWNARAAGH
DAEQVVDALV GFSRYPVPHA LLVDIADTMS RYGRLTLSKH PAHGLVLTTT DRPVLEEILR
SKKVQPLVGA RLDPDTVVVH PSERGQIKQT LLKLGWPAED LAGYVDGEAH AIELDERTWS
LRPYQQQAVE GFWHGGSGVV VLPCGAGKTL VGAGAMAQAK ATTLILVTNT VSARQWKHEL
VKRTSLTEDE IGEYSGTKKE IRPVTIATYQ VLTTKRKGVY PHLELFDSRD WGLIVYDEVH
LLPAPVFKFT ADLQARRRLG LTATLVREDG RESDVFSLIG PKRFDAPWKE IEAQGYIAPA
DCVEVRVSLT ESERLAYATA ETEEKYRYCA TTASKQSVTE ALVRRHKGEQ TLVIGQYIDQ
LDELGEHLDA PVIKGETSNA QREKLFDAFR EGEISVLVVS KVANFSIDLP EATVAIQVSG
TFGSRQEEAQ RLGRVLRPKA DGHEARFYSV VARDTVDQDF AAHRQRFLAE QGYAYRIVDA
TELLAEG
//