ID A0A1Q4WLU6_9ACTN Unreviewed; 417 AA.
AC A0A1Q4WLU6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Cysteine synthase {ECO:0000313|EMBL:OKI10961.1};
GN ORFNames=AMK13_00200 {ECO:0000313|EMBL:OKI10961.1};
OS Streptomyces sp. CB02056.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI10961.1, ECO:0000313|Proteomes:UP000186379};
RN [1] {ECO:0000313|EMBL:OKI10961.1, ECO:0000313|Proteomes:UP000186379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02056 {ECO:0000313|EMBL:OKI10961.1,
RC ECO:0000313|Proteomes:UP000186379};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI10961.1}.
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DR EMBL; LIPD01000001; OKI10961.1; -; Genomic_DNA.
DR RefSeq; WP_049648966.1; NZ_LIPD01000001.1.
DR AlphaFoldDB; A0A1Q4WLU6; -.
DR OrthoDB; 24041at2; -.
DR Proteomes; UP000186379; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR041472; BL00235/CARNS1_N.
DR InterPro; IPR040570; LAL_C2.
DR PANTHER; PTHR43585:SF2; ATP-GRASP ENZYME FSQD; 1.
DR PANTHER; PTHR43585; FUMIPYRROLE BIOSYNTHESIS PROTEIN C; 1.
DR Pfam; PF13535; ATP-grasp_4; 1.
DR Pfam; PF18130; ATPgrasp_N; 1.
DR Pfam; PF18603; LAL_C2; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000186379}.
FT DOMAIN 120..318
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 417 AA; 44857 MW; 4B0BE276B729C398 CRC64;
MHILMIECNP NGIAGIANAL ELGHDVTLVS VDPDFYLSVS PLTEAAYAHP NCQVVKSEQA
FSLDELTDLA RRLHEAKPIH GVTTYSEYHT VHTAAVAEAL GLPGMSVDGA RNARHKHLTR
TTLAGTGIRQ PRFAVATDPA EVEAAVREVG FPCVAKPSDG TASLHVLHLK DEADLREYLA
ELAQVADYGR GVVRIPEIVI EEFVTGELIS VESCVLAGGE VVNLGLTDRS LSGFPYFIEM
GLTYFSGHPL QEELFAATTA VLNGLGVDFG FIHTEWLLGP DGPVLCEVNG RLAGGIVPTL
MEITSGVDPY LEVIRQALGE RPELAFPRET TASGHWFGSP VAGTVEAIGF DALTDLPGFH
SALGYKKPGT AVNRLSRSNF DWIGHIIFTG GDRDEAAKRC QDGLDRIDLR LSVEVAR
//
