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Database: UniProt
Entry: A0A1Q4WMB7_9ACTN
LinkDB: A0A1Q4WMB7_9ACTN
Original site: A0A1Q4WMB7_9ACTN 
ID   A0A1Q4WMB7_9ACTN        Unreviewed;       846 AA.
AC   A0A1Q4WMB7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Clp protease {ECO:0000313|EMBL:OKI11131.1};
GN   ORFNames=AMK13_01340 {ECO:0000313|EMBL:OKI11131.1};
OS   Streptomyces sp. CB02056.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703924 {ECO:0000313|EMBL:OKI11131.1, ECO:0000313|Proteomes:UP000186379};
RN   [1] {ECO:0000313|EMBL:OKI11131.1, ECO:0000313|Proteomes:UP000186379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02056 {ECO:0000313|EMBL:OKI11131.1,
RC   ECO:0000313|Proteomes:UP000186379};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC       {ECO:0000256|ARBA:ARBA00026057}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKI11131.1}.
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DR   EMBL; LIPD01000001; OKI11131.1; -; Genomic_DNA.
DR   RefSeq; WP_074000790.1; NZ_LIPD01000001.1.
DR   AlphaFoldDB; A0A1Q4WMB7; -.
DR   OrthoDB; 9803641at2; -.
DR   Proteomes; UP000186379; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:OKI11131.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:OKI11131.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186379};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}.
FT   DOMAIN          36..179
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   REGION          173..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          446..492
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   846 AA;  92217 MW;  AB535708F354F666 CRC64;
     MTMPPFGSND PFSDLLSRFF GMSPMASPPA VQRVPIGRLL SESSQELLAL AAQRAAEDGS
     SDLDTAHLAW AATRVDPSRR MLERAGIDPD RLSGDLEHAL PSGNPETVDG RPALTPSAKR
     ALLAAHARSQ EAGASYIGPE HILGALLDQE RSGAGVALRN AAPSQEALKS VLEGRGTGGE
     RSSTGAHPSE TPTLDEYGRD LTEEARSGRL DPVVGRAEEI EQTVEILSRR TKNNPVLIGE
     PGVGKTAIVE GLAQRIVSGD VPQSLREKRV VTLDLTALVA GSKYRGEFEE RLKNVIDEVT
     AAEKSVILFL DELHTVVGAG GGGEGSMDAG NILKPALARG ELSVVGATTL DEYRKHVEKD
     AALERRFQPV LVPEPSVEET IEILQGLRDA YEAHHQVRFT DEALDAAATL SDRYVSDRFL
     PDKAIDLLDQ AGARVRLRSL SGSTEATGVR DRITKLKREL DEAVADEEFV RAANLKTELR
     QTEDELAAVA ESREEVVDVT ADDIAQVLSS RTGIPVAELN ATEKERLLKL EDHLHQKVIG
     QDEAVTAVSQ AVRRGRAGMG DPERPTGSFL FLGPTGVGKT ELAKALAALL FGDPDRMIRF
     DMSEFQEKHT VSRLVGSPPG YVGYEEAGQL TEAVRRKPYS VLLFDEVEKA HPDVFNLLLQ
     VLDDGRLTDS QGRTVDFRNT VVIMTSNIGS QRILDHAGNV DEIRDDLMRD LRQHFRPEFL
     NRIDEVIVFH ALTRKDLLSV VDLLLERSRR RLRAQDIRLE VTEAAKEYLV NRGYQPEFGA
     RPLRRTIQSE LDNRISNLLL DGSVREGDTL IAEVSDGELV VTLARPEASA TFEEAEAKAA
     AAAAEG
//
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