ID A0A1Q4X3D3_9ACTN Unreviewed; 338 AA.
AC A0A1Q4X3D3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Methyltransferase {ECO:0000313|EMBL:OKI16888.1};
GN ORFNames=A6A08_06310 {ECO:0000313|EMBL:OKI16888.1};
OS Nocardiopsis sp. TSRI0078.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1718951 {ECO:0000313|EMBL:OKI16888.1, ECO:0000313|Proteomes:UP000185866};
RN [1] {ECO:0000313|EMBL:OKI16888.1, ECO:0000313|Proteomes:UP000185866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0078 {ECO:0000313|EMBL:OKI16888.1,
RC ECO:0000313|Proteomes:UP000185866};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI16888.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLB01000023; OKI16888.1; -; Genomic_DNA.
DR RefSeq; WP_073703535.1; NZ_LWLB01000023.1.
DR AlphaFoldDB; A0A1Q4X3D3; -.
DR STRING; 1718951.A6A08_06310; -.
DR OrthoDB; 4145676at2; -.
DR Proteomes; UP000185866; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:OKI16888.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:OKI16888.1}.
FT DOMAIN 11..83
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 111..316
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 246
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 338 AA; 36346 MW; 3D28DDD2BF1CD055 CRC64;
MTGNGSAERE VLRLMTGPWV ARAVATAVEL GVLDRLAEDA ADDADGLAAE LDLHPDRLGR
LLRLLAAVGV LREQRGRYRP TEVGAALRRG HPSGMADLAL LYDSDMFTSA WTRLADTVRT
GEPAFEAAHG TDAFTYLEDH PEDAARYTAG MAASGRFSTA IPDVHDFTGA RVVVDLGGGD
GELLAAVLTR APRARGVLVE RPPALAAART RLGAFVDAGR CELVEGDFLR GVPAGADVYL
LSRVLHNWSD EDARAVLRHC REAMAPDGLV LIAERVLPDD GRPWLSSVLD AHMMVMTTGA
ERTEREYEAL LRSAGLTTRR ILDLLLEMRL LVAGPAAP
//
