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Database: UniProt
Entry: A0A1Q4X9U2_9ACTN
LinkDB: A0A1Q4X9U2_9ACTN
Original site: A0A1Q4X9U2_9ACTN 
ID   A0A1Q4X9U2_9ACTN        Unreviewed;       353 AA.
AC   A0A1Q4X9U2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 10.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=A6A08_05915 {ECO:0000313|EMBL:OKI19121.1};
OS   Nocardiopsis sp. TSRI0078.
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Nocardiopsis.
OX   NCBI_TaxID=1718951 {ECO:0000313|EMBL:OKI19121.1, ECO:0000313|Proteomes:UP000185866};
RN   [1] {ECO:0000313|EMBL:OKI19121.1, ECO:0000313|Proteomes:UP000185866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TSRI0078 {ECO:0000313|EMBL:OKI19121.1,
RC   ECO:0000313|Proteomes:UP000185866};
RX   PubMed=27999165;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural
RT   Products.";
RL   MBio 7:e02104-16(2016).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OKI19121.1}.
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DR   EMBL; LWLB01000012; OKI19121.1; -; Genomic_DNA.
DR   RefSeq; WP_073702774.1; NZ_LWLB01000012.1.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000185866; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000185866};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       43    337       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   353 AA;  37335 MW;  3D474AE59FF64D65 CRC64;
     MPSTNDTRVA SYKPLIAPGD LLAELPLGPE RSSLVEDSRA EVKRVLDGDD DRLLVVVGPC
     SVHDPESAMD YAHRLAELVP SLRDELCVVM RVYFEKPRTT VGWKGLINDP GLDDTYDVHR
     GLRTARKLLL DINSLGLPAG TEFLDPITPQ YIADVVSWGA IGARTTESQV HRQLSSGLST
     PVGFKNGTDG DVQVAVDAVG AAAASHTFFG VDPAGAGSVV VTEGNPDCHV ILRGGRSGPN
     FGAEPVNAAL DVIEGSGLPR RLMIDASHAN SGKDHTRQPG VASAIAAQVA EGQKGIIGVM
     LESFIVEGAQ KLGDPADLTY GQSITDKCMG WETTGEVLSQ LAEAVRQRRK NAG
//
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