ID A0A1Q4XFD3_9ACTN Unreviewed; 380 AA.
AC A0A1Q4XFD3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:OKI21083.1};
GN ORFNames=A6A08_21735 {ECO:0000313|EMBL:OKI21083.1};
OS Nocardiopsis sp. TSRI0078.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1718951 {ECO:0000313|EMBL:OKI21083.1, ECO:0000313|Proteomes:UP000185866};
RN [1] {ECO:0000313|EMBL:OKI21083.1, ECO:0000313|Proteomes:UP000185866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0078 {ECO:0000313|EMBL:OKI21083.1,
RC ECO:0000313|Proteomes:UP000185866};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI21083.1}.
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DR EMBL; LWLB01000006; OKI21083.1; -; Genomic_DNA.
DR RefSeq; WP_073701809.1; NZ_LWLB01000006.1.
DR AlphaFoldDB; A0A1Q4XFD3; -.
DR STRING; 1718951.A6A08_21735; -.
DR OrthoDB; 3761315at2; -.
DR Proteomes; UP000185866; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:OKI21083.1}.
FT DOMAIN 5..249
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 257..379
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 336
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 366
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 380 AA; 40145 MW; 8D0FE46E217D12E1 CRC64;
MAEAYIVGAV RTPVGTKKGA LAAVHPADLG AHVLKELVTR TDVDPAAVED VIMGCVSQVG
PQALDLARTA WLSAGFPESV PGVTIDRQCG SSQQAVHFAA QGVMSGTQDL VVASGVENMG
MVPMGANVQY AIDNGLGLYG DGWVERYGLQ EVSQFRGAQL MCEKWGFKRE QLEEFALESH
QRAAKALEAG YFDDQVAPLA GVERDEGVRP DTTLEKMAGL KPLREDWELT AAVASQISVG
ASAVLLASER AVKQHNLTPL ARIVQLSLVG DDPVYMLTAP IPATRIALEK AGLGIDDIDV
TEINEAFAPV PMSWIQELGA DPAKVNPNGG AIALGHPLGA TGTVLMTKLV NELHRTGGRY
GLQTMCEGGG QANTTIIERV
//
