ID A0A1Q4YDA9_9ACTN Unreviewed; 545 AA.
AC A0A1Q4YDA9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Long-chain fatty acid--CoA ligase {ECO:0000313|EMBL:OKI32414.1};
GN ORFNames=A6A29_23215 {ECO:0000313|EMBL:OKI32414.1};
OS Streptomyces sp. TSRI0281.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718998 {ECO:0000313|EMBL:OKI32414.1, ECO:0000313|Proteomes:UP000186952};
RN [1] {ECO:0000313|EMBL:OKI32414.1, ECO:0000313|Proteomes:UP000186952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0281 {ECO:0000313|EMBL:OKI32414.1,
RC ECO:0000313|Proteomes:UP000186952};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI32414.1}.
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DR EMBL; LWLE01000037; OKI32414.1; -; Genomic_DNA.
DR RefSeq; WP_073728847.1; NZ_LWLE01000037.1.
DR AlphaFoldDB; A0A1Q4YDA9; -.
DR STRING; 1718998.A6A29_23215; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000186952; Unassembled WGS sequence.
DR GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR CDD; cd12119; ttLC_FACS_AlkK_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF11; MEDIUM-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:OKI32414.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186952}.
FT DOMAIN 18..396
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 445..519
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 545 AA; 58816 MW; 592989E962888E66 CRC64;
MLSTMQRHPL TVTTLLRHGA TVHGRSEAVT WTGGAARRAT YAEVALRATR LAAALRGLGV
TGDQRVATLM WNNQEHLEAY LAIPSMGAVL HTLNLRLPAD QLRHIARHAE DRVVLADASL
VPLIAPLLPG LPAVEHLVVV GEGPLPHLPG VRVHRYEELL ACAPRDFDWP EIDEDAAAAM
CYTSGTTGDP KGVVYSHRSI YLHSMQVCMP EALCLDDTKR ALAVVPMFHA MAWGLPYAAF
MAGTSLLLPG PHLQAEPLAG FIAAEKPHTA AAVPTVWAAL LAHLDTHGGD VSSLREVLVG
GAACPPSLMT GFEERHGVRV VAAWGMTETS PLGTVARAPH HVRSPEGAML YRSTAGRPPA
GVELRLTGED GTVLANDGAT VGEVEVRGPW VTGSYHLAGA PSDKFNDGWL RTGDLGTLTS
DSYLRLTDRA KDVIKSGGEW ISSVELENHL MAHPEVREAA VIGVPDDRWD ERPLAVVVWA
GEAGDYAGLR THLGDRVARW QLPERWSALP EIPRTSVGKF DKKELRRRYA QDELPVERLS
PSAAV
//
