ID   A0A1Q4YDC4_9PSEU        Unreviewed;       268 AA.
AC   A0A1Q4YDC4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=16S/23S rRNA (Cytidine-2'-O)-methyltransferase {ECO:0000313|EMBL:OKI32595.1};
GN   ORFNames=A6A25_26135 {ECO:0000313|EMBL:OKI32595.1};
OS   Saccharothrix sp. CB00851.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharothrix.
OX   NCBI_TaxID=1835005 {ECO:0000313|EMBL:OKI32595.1, ECO:0000313|Proteomes:UP000186828};
RN   [1] {ECO:0000313|EMBL:OKI32595.1, ECO:0000313|Proteomes:UP000186828}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB00851 {ECO:0000313|EMBL:OKI32595.1,
RC   ECO:0000313|Proteomes:UP000186828};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- SIMILARITY: Belongs to the TlyA family.
CC       {ECO:0000256|ARBA:ARBA00029460}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKI32595.1}.
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DR   EMBL; LWLC01000013; OKI32595.1; -; Genomic_DNA.
DR   RefSeq; WP_073890542.1; NZ_LWLC01000013.1.
DR   AlphaFoldDB; A0A1Q4YDC4; -.
DR   STRING; 1835005.A6A25_26135; -.
DR   Proteomes; UP000186828; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR004538; Hemolysin_A/TlyA.
DR   InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR047048; TlyA.
DR   NCBIfam; TIGR00478; tly; 1.
DR   PANTHER; PTHR32319; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR   PANTHER; PTHR32319:SF0; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR   Pfam; PF01728; FtsJ; 1.
DR   Pfam; PF01479; S4; 1.
DR   PIRSF; PIRSF005578; TlyA; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:OKI32595.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186828};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182};
KW   Transferase {ECO:0000313|EMBL:OKI32595.1}.
FT   DOMAIN          5..71
FT                   /note="RNA-binding S4"
FT                   /evidence="ECO:0000259|SMART:SM00363"
SQ   SEQUENCE   268 AA;  28330 MW;  BB28AC63F26EEC30 CRC64;
     MPRRARLDAE LVRRGLARSR EHASQLVAEG RVTVRGTVAT KPATAVELDT ALVVRETDDP
     NYASRGAHKL VGALEVFDGV DVKGRRCLDA GASTGGFTDV LLRAGARQVV AADVGRGLLD
     WRLRTDDRVV VKDKTNVRSL TPEDIGGPVE LVVADLSFIS LRLVLPALAA CLDEEGDLLP
     MVKPQFEVGK ERLGSGGVVR DPELRAEAVL DVVASAAGLG LRLHGVTASP LPGPSGNVEF
     FVWLRRGEAL DAADATALVR AAVAEGPQ
//