ID A0A1Q4YHU4_9ACTN Unreviewed; 980 AA.
AC A0A1Q4YHU4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Topoisomerase II {ECO:0000313|EMBL:OKI34054.1};
GN ORFNames=A6A29_17270 {ECO:0000313|EMBL:OKI34054.1};
OS Streptomyces sp. TSRI0281.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718998 {ECO:0000313|EMBL:OKI34054.1, ECO:0000313|Proteomes:UP000186952};
RN [1] {ECO:0000313|EMBL:OKI34054.1, ECO:0000313|Proteomes:UP000186952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0281 {ECO:0000313|EMBL:OKI34054.1,
RC ECO:0000313|Proteomes:UP000186952};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI34054.1}.
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DR EMBL; LWLE01000035; OKI34054.1; -; Genomic_DNA.
DR RefSeq; WP_073726668.1; NZ_LWLE01000035.1.
DR AlphaFoldDB; A0A1Q4YHU4; -.
DR STRING; 1718998.A6A29_17270; -.
DR OrthoDB; 3204399at2; -.
DR Proteomes; UP000186952; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047739; SCO5717-like_N.
DR NCBIfam; NF041021; SCO5717_Nterm; 1.
DR PANTHER; PTHR43384:SF14; ESX-1 SECRETION-ASSOCIATED PROTEIN ESPI; 1.
DR PANTHER; PTHR43384; SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:OKI34054.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186952}.
FT DOMAIN 578..723
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT REGION 1..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..70
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..126
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..306
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..432
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..467
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..497
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..916
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..980
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 101565 MW; 61219BBA7F86829F CRC64;
MNGDRDEIRG GWNTPVDESS DADPAEMTGE FTIDYTPPAW YTQNATGDSA GGSGSHLAPP
PPPHGAPVSV PGPPAAGGFD PNWAPAPPAP AASPPVPAPT APASSVPPPS VPTSSVPSPE
AVPPVAPVSA SAPSEEAGGG GGDLESGTTM RFSPAALKRE IAEREAAAAP SPDAGGSGPD
GGAPDSGTRE AAEAGAQENG APDATSAADR DENAPDSGTD ADAVADDLRS AGGTEESANA
DSPDAPADEA PAVTDPTAPA DAHPLAVTDA VPQDVPQAAA PAPWSPAPPA PGALPPLPPA
FQPAAPQPTA PQSAAQWPSP VPANEAPGGY GFPRPAQTAQ PAQVPHQAPQ AHQAPQPHQH
LPAQQQAPQQ PPQHQQFQQF PGQGAPLPPQ APQAGGGYGF PQQQGGYGFP QAPQAPQAPQ
APQAPHPSFP AQGAAPLPAQ QPGQGSPNLP APIAPRAPQP PEPYQPQQHL PAQQQAPQQQ
APQQPGPQAP PVDPRTGTSW PTPVTHDQRE RSVPGAPLGY TAAVELSSDR LVRGKQKAKS
SRTPSGVSRF KLGGKKEEIE RQRKLELIRT PVLSCYRIAV ISLKGGVGKT TTTTALGSTL
ATERQDKILA IDANPDAGTL GRRVRRETGA TIRDLVQAIP YLNSYMDIRR FTSQAPSGLE
IIANDVDPAV STTFNDEDYR RAIEVLGKQY PIILTDSGTG LLYSAMRGVL DLADQLIIIS
TPSVDGASSA STTLDWLSAH GYADLVQRSI TVISGVRETG KMIKVDDIVQ HFETRCRGVV
VVPFDEHLSA GAEVDLDMMR PKTREAYFHL SAMVAEDFSR AQQQQGLWTS DGSMPPQFAP
PMPGQQQPGQ PMPGQPMPGQ QQPGQPMPGQ QPYPPQQPQP GQPYPQQPYG GQPPYGGPQA
PQQQPPQQPY PPQPGPGAQQ NWQQNGWQQQ SLPSQAQSGA SPAGPPPPAG QPGGQSELQG
PVPPAGWQQT PPQPPPAPQQ
//
