ID A0A1Q4YIJ4_9ACTN Unreviewed; 1013 AA.
AC A0A1Q4YIJ4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=PLD phosphodiesterase domain-containing protein {ECO:0000259|PROSITE:PS50035};
GN ORFNames=A6A29_19240 {ECO:0000313|EMBL:OKI34399.1};
OS Streptomyces sp. TSRI0281.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718998 {ECO:0000313|EMBL:OKI34399.1, ECO:0000313|Proteomes:UP000186952};
RN [1] {ECO:0000313|EMBL:OKI34399.1, ECO:0000313|Proteomes:UP000186952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0281 {ECO:0000313|EMBL:OKI34399.1,
RC ECO:0000313|Proteomes:UP000186952};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI34399.1}.
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DR EMBL; LWLE01000035; OKI34399.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4YIJ4; -.
DR STRING; 1718998.A6A29_19240; -.
DR Proteomes; UP000186952; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0006793; P:phosphorus metabolic process; IEA:UniProt.
DR CDD; cd09126; PLDc_C_DEXD_like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR043764; DUF5710.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18974; DUF5710; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 1.
DR PROSITE; PS50035; PLD; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186952}.
FT DOMAIN 873..900
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 126..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 407..434
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 923..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 111309 MW; C643D39E92D53580 CRC64;
MDELLRAAQL EIAAELRSDG GNKPKASLRE GRRLSVSGPQ HEYEFSFKRW PEALNGMPLL
VRPSRSQGPW TPAEVTRLPD NKVRFVTEAD LGHAPGQVQL RADESQTWKV LAERLASVGE
ADHPVRPESA GWITGQGSPK VGREADPGRW VADWPSLRLN PPQRQAVEQA LASEVTFLWG
PPGTGKTDVV AHIVEGCSRQ GLNVLFLAPT KVAVDQALER ICDLLSGEQG FDTGLVQRAG
GIDVESLRER YGAYVDPEQV AARLSAHLQS ELTQLTSALT TVRSGIALHE RLRSLHEDLV
AARAAYGSAG AARQKAGQAS SDALEIADAM GARIRRIGTP SGFFADQKQA KLDAARTDLW
KASQQALEAN EARDAAKTAQ DKAARDISRI GTDITDQNAK LEGVEPLRTL TERTDVLQKQ
INAAEKELRR ISDAVRANCR VLGATVAKAA QSRSLLERTD VVVIDEAGMI NLPMAWYVAG
LAGKRVVVAG DFRQLPAVNK AADDRGASEE DKAHARQWSA TDAFRAAGLV TAAGTVRQDP
RLVALSTQYR MREPICDLVN AVAYPDAPLR TGRDNESRIP FSPLVNAPVI LIDTSGHCVP
GPNHRTNPVH QAAVHELVRG LQYDGVLPPR KWENVPPGER ATDRLAVIAP YKDQVKGLKR
VLTERLGADY DGLVESVHRF QGSQRPVVIL DTVAGAGDYP GHFYRGTGLD SETCRLLNVA
LSRAQDHLVV IADVAFLRKK LPQRSEARTM LDHLESRAQS ISVDQLIPIR SAAELAALPD
EELTRPAFFP AEQVDRAVHW DIERARESID IYTFLLAVPR VKRWLALLEE KAAAGVRVVI
HTRSPEEQRE DSVVERHRGL VDQLKEAGCT VEYRERMHEK VFIVDGTVLW HGSLNLLGNL
GPTDLMMRLE DADSCAQARR VMDQARRESP VYRGGGRPHR DSGSSRKGNP KAAEGVEVGA
TVWGRLYLNV SYQEKDEAKR LVSARFDGDN KLWYTDAAQV IPQGKQGWLR PKH
//
