ID A0A1Q4YK44_9ACTN Unreviewed; 434 AA.
AC A0A1Q4YK44;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Cyclopropane-fatty-acyl-phospholipid synthase {ECO:0000313|EMBL:OKI34947.1};
GN ORFNames=A6A29_16085 {ECO:0000313|EMBL:OKI34947.1};
OS Streptomyces sp. TSRI0281.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718998 {ECO:0000313|EMBL:OKI34947.1, ECO:0000313|Proteomes:UP000186952};
RN [1] {ECO:0000313|EMBL:OKI34947.1, ECO:0000313|Proteomes:UP000186952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0281 {ECO:0000313|EMBL:OKI34947.1,
RC ECO:0000313|Proteomes:UP000186952};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the CFA/CMAS family.
CC {ECO:0000256|ARBA:ARBA00010815}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI34947.1}.
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DR EMBL; LWLE01000034; OKI34947.1; -; Genomic_DNA.
DR RefSeq; WP_073726062.1; NZ_LWLE01000034.1.
DR AlphaFoldDB; A0A1Q4YK44; -.
DR STRING; 1718998.A6A29_16085; -.
DR OrthoDB; 9782855at2; -.
DR Proteomes; UP000186952; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003333; CMAS.
DR InterPro; IPR020803; PKS_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43667; CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE; 1.
DR PANTHER; PTHR43667:SF1; CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE; 1.
DR Pfam; PF02353; CMAS; 1.
DR PIRSF; PIRSF003085; CMAS; 1.
DR SMART; SM00828; PKS_MT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000186952};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 156..396
FT /note="Polyketide synthase methyltransferase"
FT /evidence="ECO:0000259|SMART:SM00828"
SQ SEQUENCE 434 AA; 48255 MW; 59955A955A26C319 CRC64;
MADAASRLTA LAEELLGKPL PVRIRAWDGS ESGPPGAPAL VIRHRRALRR LLWKPGELGL
ARAWVAGEID VEGNLYEALD HLAGLLWERG ADAKDSVHPL RDPGVRAFAR GLVELAGPWP
PPAPPAEEVR RRAGAMHTKR RDKKAISHHY DVGNDFYELV LGPSMVYSCA YWEDGGSLED
AQRDKLDLVC RKLALKEGDR LLDVGCGWGS MAIHAAREYG ARVTGVTLSI EQAAFARKRI
AEEGLTDRIE IRVQDYRDVR DGPYDAISSI GMAEHVGSVR YREYADDLYA LLKPGGRLLN
HQIARRPEKD EDAYRIDEFI DAYVFPDGEL APVGRTVGTL EEAGFEVRDV EAIREHYALT
LRRWVANLEQ HWQRAVRATS PGRARVWRLY MAASALSFEH NKIGVNQILV VRPTEGGGAR
MPLRARAWTA SATG
//
