ID A0A1Q4YXK4_9PSEU Unreviewed; 342 AA.
AC A0A1Q4YXK4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:OKI39300.1};
GN ORFNames=A6A25_03880 {ECO:0000313|EMBL:OKI39300.1};
OS Saccharothrix sp. CB00851.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1835005 {ECO:0000313|EMBL:OKI39300.1, ECO:0000313|Proteomes:UP000186828};
RN [1] {ECO:0000313|EMBL:OKI39300.1, ECO:0000313|Proteomes:UP000186828}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB00851 {ECO:0000313|EMBL:OKI39300.1,
RC ECO:0000313|Proteomes:UP000186828};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI39300.1}.
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DR EMBL; LWLC01000001; OKI39300.1; -; Genomic_DNA.
DR RefSeq; WP_073886267.1; NZ_LWLC01000001.1.
DR AlphaFoldDB; A0A1Q4YXK4; -.
DR STRING; 1835005.A6A25_03880; -.
DR Proteomes; UP000186828; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186828}.
FT DOMAIN 22..197
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 342 AA; 37105 MW; DA0A5000577BF1B8 CRC64;
MAAPTMDRPT ADSTGAPAVQ TLTIAKALNN GLRASMEANP KVIVMGEDVG KLGGVFRITD
GLQKDFGEQR VLDTPLAESG IIGTAVGLAI RGYRPVCEIQ FDGFIFPGFD QIVSQVAKLH
FRTQGRLKVP MVIRVPFGGG IGAVEHHSES PESYFAHTAG LKVVSCSNPA DAYWMIQQAI
DCDDPVLFFE PKRRYYEKGE VDTTAAPGPL FSSRTLRTGS DVTLVTYGPM VRTSLDAAAA
AEEEGRSLEV IDLRTLSPLD LAPVYESVRR TGRLVVVTEA PSESSISSEI AAKVQQECFY
SLQAPVLRVT GFDTPYPPSK LEEEFLPDLD RVLHAVDRSL AW
//
