ID A0A1Q4Z1V5_9ACTN Unreviewed; 740 AA.
AC A0A1Q4Z1V5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN ORFNames=A6A29_38935 {ECO:0000313|EMBL:OKI40765.1};
OS Streptomyces sp. TSRI0281.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718998 {ECO:0000313|EMBL:OKI40765.1, ECO:0000313|Proteomes:UP000186952};
RN [1] {ECO:0000313|EMBL:OKI40765.1, ECO:0000313|Proteomes:UP000186952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0281 {ECO:0000313|EMBL:OKI40765.1,
RC ECO:0000313|Proteomes:UP000186952};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI40765.1}.
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DR EMBL; LWLE01000018; OKI40765.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4Z1V5; -.
DR STRING; 1718998.A6A29_38935; -.
DR Proteomes; UP000186952; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd05195; enoyl_red; 1.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186952}.
FT DOMAIN 227..533
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 740 AA; 77973 MW; 0C0BFD4936B77551 CRC64;
MTLSPRHAGK ESTVPAQVDL LQAEWIPAPA ATPPPDWAIL GPPSTLAGQL SAAYPQVPLL
ALGPALSEAP TARRTTRWPP VILVVPHSAT PRDDASQTAA RTVPALVQAA LAEKGAPRLV
FLTQDAVTAR SADVVTEPGQ GVLRELVLAA QAEHPGRFSL IDIDRETASL PAVSAALGTP
LPQQAIRSGT ILTLRAGAVR LLPDVTGPPL LSPPGGQPWR LTLVGKGTLD NLALEPSPDV
ERLLVGDQVR IAVQAAGVNF RDVLDTFGLY PGDPGPLGAE GAGIVLETGP QARRLAPGDR
VMGLLTGAFG PIAVSEEPLL VTVPQGWSAE RAAAVPVAFA TAWYALHDLA ALRAGERVLI
HCATGGVGSA AVEIAHYLGA EVFATAGPSK HPVLRERDIA DDHLASSRST DFEQQFLATT
CGRGLDVVLN ALAHEATDAA LRLVRPGGRF IEMGKTDLRD PGQVADDHLG VDYQAFELKD
AGPRRIGEIL SELRRLLTTG ALRPPAVHTF DVRDAVHAFH HMSRARHTGK IVLRIPPPPE
HRGSALLTGP VSDTAPLALH LATRYGTDDI WLVGPNHSGG STAEQLRTRL DALHTRLHMI
DADANDSEAL RRAVGGIPAS SPLTTVVHTA AGAALTAAAT LDRLTRDLPL GAFLILAPTS
PDIPRRSPHD LLGHHARLEE VVAHRRASGR AATLLVLPPD SPPAPDLLPA LYDAAQRADR
PMLLLTDRAA HDPRAHHGVR
//