ID A0A1Q4ZAW8_9ACTN Unreviewed; 606 AA.
AC A0A1Q4ZAW8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Vanomycin resistance protein VanB {ECO:0000313|EMBL:OKI43857.1};
GN ORFNames=A6A27_38735 {ECO:0000313|EMBL:OKI43857.1};
OS Micromonospora sp. CB01531.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1718947 {ECO:0000313|EMBL:OKI43857.1, ECO:0000313|Proteomes:UP000186700};
RN [1] {ECO:0000313|EMBL:OKI43857.1, ECO:0000313|Proteomes:UP000186700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01531 {ECO:0000313|EMBL:OKI43857.1,
RC ECO:0000313|Proteomes:UP000186700};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI43857.1}.
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DR EMBL; LWLS01000134; OKI43857.1; -; Genomic_DNA.
DR RefSeq; WP_073839802.1; NZ_LWLS01000134.1.
DR AlphaFoldDB; A0A1Q4ZAW8; -.
DR OrthoDB; 9813301at2; -.
DR Proteomes; UP000186700; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007391; Vancomycin_resist_VanW.
DR InterPro; IPR022029; YoaR-like_PG-bd.
DR PANTHER; PTHR35788; EXPORTED PROTEIN-RELATED; 1.
DR PANTHER; PTHR35788:SF1; EXPORTED PROTEIN-RELATED; 1.
DR Pfam; PF12229; PG_binding_4; 1.
DR Pfam; PF04294; VanW; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186700};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 51..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..359
FT /note="YoaR-like putative peptidoglycan binding"
FT /evidence="ECO:0000259|Pfam:PF12229"
FT REGION 22..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 64136 MW; 5BE71A79B9A103E8 CRC64;
MTLYGEKLPP ADDRPTVRVT AVNWPDDGSE PTVAPTPEPP GGRLRSRRGR LLLAGGIVAA
VLAAGTGLGA YAYAGDVPRG TTVLGAELGG RSRAEAVRAL RTELDRRSAA LTAPIAVTVG
EKSVQVKPAD VGLAIDVDAT VAAATAAEAH PVSRLVGSRA VDPVVTVDAA RLDAALQKAK
GDQGREMTMP AIIFTGTTPK PVYPKPALTV DSAGAVDVVK AGWLAGKPVT VPLVEKWPAT
TREEVDRLVA ELAKPAVAAP VTLTTSRGSV TIPPAAIASG LRFSADDAGK LTPRVDVKRL
RAALGDRLAK IEVEPKDAGL TISGGKPKVV PGRSGQQVDS ATLGRELLAV LPKADGRTVT
AELKPAEPEL TEAKLAELGI KERVSTFTTR FPGGLSSPRS QNIVQAAKDV DGTIVKPGET
FSLNGHTGER GYDQGYQDAP TIVNGKLVPG VGGGVSQFTT TLFNATYYAG LEDVEHKPHS
FYFSRYPAVI ESTIYWPQLD FKFRNNTQYG VLIDTSYAAS TITVSIWSTK IYDSVTTEYG
PRRDITQPKT VYLDPGPKCI AAAGSVGFAQ DAYRVIKKDG KVIKREKFSW RYDPEPRFIC
APKPAD
//
