ID A0A1Q4ZH56_9ACTN Unreviewed; 396 AA.
AC A0A1Q4ZH56;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Saccharopine dehydrogenase {ECO:0000313|EMBL:OKI46183.1};
GN ORFNames=A6A29_28940 {ECO:0000313|EMBL:OKI46183.1};
OS Streptomyces sp. TSRI0281.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718998 {ECO:0000313|EMBL:OKI46183.1, ECO:0000313|Proteomes:UP000186952};
RN [1] {ECO:0000313|EMBL:OKI46183.1, ECO:0000313|Proteomes:UP000186952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0281 {ECO:0000313|EMBL:OKI46183.1,
RC ECO:0000313|Proteomes:UP000186952};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI46183.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLE01000004; OKI46183.1; -; Genomic_DNA.
DR RefSeq; WP_073719771.1; NZ_LWLE01000004.1.
DR AlphaFoldDB; A0A1Q4ZH56; -.
DR STRING; 1718998.A6A29_28940; -.
DR OrthoDB; 4369409at2; -.
DR Proteomes; UP000186952; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186952};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..140
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 396 AA; 42638 MW; 194EC0FA3DE5A88D CRC64;
MNRQSGAKRP YDVVLFGATG FVGVLTAEYL AANAPAGCRW ALAGRDRAKL ERLRERLTAI
EPRCAELPLV RADADDADAL RALAESARVV ATTVGPYVWY GEKLVAACAE AGTDYVDLTG
EAEFIDRVYL EHDTRARETG TRLVHACGFD SVPHDLGAYF TVQQLPRDVP LVIDGFVRSN
AAFSGGTFAS ALTAMGRGPQ MLQAAKERRL HEPRLVGRRV RAPLGTPHFS AATGTWALPL
PTVDARIIGR SARALERYGP DFQYRHFASV KHLPVAIGST AALGALVTAA QLPSVREWLM
SRYEPGEGPD AERRKRSWFT VRFVGEGGGR RVFTEVSGGD PGYGETAKML AESALCLALD
ELPATSGQVT TAVAMGDALL ERLRAAGLGF RVAAVR
//
