ID A0A1Q4ZJJ1_9ACTN Unreviewed; 384 AA.
AC A0A1Q4ZJJ1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:OKI46897.1};
GN ORFNames=A6A29_25460 {ECO:0000313|EMBL:OKI46897.1};
OS Streptomyces sp. TSRI0281.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1718998 {ECO:0000313|EMBL:OKI46897.1, ECO:0000313|Proteomes:UP000186952};
RN [1] {ECO:0000313|EMBL:OKI46897.1, ECO:0000313|Proteomes:UP000186952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0281 {ECO:0000313|EMBL:OKI46897.1,
RC ECO:0000313|Proteomes:UP000186952};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI46897.1}.
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DR EMBL; LWLE01000002; OKI46897.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q4ZJJ1; -.
DR STRING; 1718998.A6A29_25460; -.
DR Proteomes; UP000186952; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06142; RNaseD_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR041605; Exo_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF18305; DNA_pol_A_exoN; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000313|EMBL:OKI46897.1};
KW Hydrolase {ECO:0000313|EMBL:OKI46897.1};
KW Nuclease {ECO:0000313|EMBL:OKI46897.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186952}.
FT DOMAIN 204..284
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 280..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 384 AA; 41664 MW; 70455AF2007ACE54 CRC64;
MVASDDDLAE VVAAFAAGTG PVAVDAERAS GYRYGQRAYL VQLRRAGAGS ALIDPVGCPD
LTALGEALTD SEWILHAATQ DLPCLREIGM IPTGLFDTEL AGRLAGFPRV GLGAMVESVL
GFALEKGHSA VDWSTRPLPD PWLRYAALDV ELLIDLRDAL EEELDRQGKL EWAREEFDAI
ASAPPAPPRK DPWRRTSGMH KVRRRRQMAV VRELWNTRDQ VAQRRDISPG KVLGDGAIVE
AALALPATVQ ALTALPGFGH RMGRRQLEQW QAAVDRAKAL PDPELPQPGQ QVAGPPPPRS
WADKDPEAAA RLSAARAAVS ELAERLHMPQ ENLITPDTVR RVCWEPPKSH TPGAVEDALA
GYGARHWQIE QVGPILLRAL DAGV
//
