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Database: UniProt
Entry: A0A1Q5AAH1_9ACTN
LinkDB: A0A1Q5AAH1_9ACTN
Original site: A0A1Q5AAH1_9ACTN 
ID   A0A1Q5AAH1_9ACTN        Unreviewed;       649 AA.
AC   A0A1Q5AAH1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:OKI56031.1};
GN   ORFNames=A6A27_30840 {ECO:0000313|EMBL:OKI56031.1};
OS   Micromonospora sp. CB01531.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1718947 {ECO:0000313|EMBL:OKI56031.1, ECO:0000313|Proteomes:UP000186700};
RN   [1] {ECO:0000313|EMBL:OKI56031.1, ECO:0000313|Proteomes:UP000186700}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01531 {ECO:0000313|EMBL:OKI56031.1,
RC   ECO:0000313|Proteomes:UP000186700};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- SIMILARITY: Belongs to the terpene synthase family.
CC       {ECO:0000256|ARBA:ARBA00006333}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKI56031.1}.
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DR   EMBL; LWLS01000086; OKI56031.1; -; Genomic_DNA.
DR   RefSeq; WP_073837269.1; NZ_LWLS01000086.1.
DR   AlphaFoldDB; A0A1Q5AAH1; -.
DR   STRING; 1718947.A6A27_30840; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000186700; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186700};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          32..312
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          326..636
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   649 AA;  70904 MW;  765EBED820DCC7A8 CRC64;
     MTELLSSKPK PTTSPTTTAG GTASDPAWAA LRRARDHLLG LQDDAGWWKG NLATNVTMDA
     EDLLLRQFLG IRTAEQTAES ARWIRSQQRP DGSWATFHGG PGDLSTTIEA YLALRLAGDT
     PDAPHLAAAA RFVRARGGLA ASRVFTRFWL ALFGHWPWSQ LPAVPPELVL LPHWMPFNVY
     DFACWARQTI VPLSIVRALR PVRELGFGVD ELCVPTAASR PPRLRSRAGV LHRLDRVASG
     YERIARGPVR RHALRRAAEW IVARQEADGS WGGIQPPWVY SLMALHLLGY PLDHPVLRAG
     LDGLERFTVR EQTEDGPVRW LEACQSPVWD TALAVTALSD AGLPAGHAAL ERAGNWLLKE
     EIRVRGDWAI RRPKTPVGGW AFEFENDGYA DTDDTAEVIM ALRRTGVPAE AAVLRGTRWL
     LGMQCRDGGW GAFDADNTRA IVGDLPFCDF GEVTDPPSAD VTAHIVEALA AENFAGTAPV
     RRGVHWLLRA QEPDGSWFGR WGANHVYGTG AVVPALVAAG VKPGHPAIRA AVDWLHAHQN
     PDGGWGEDMR SYRDPSWIGR GESTASQTAW ALLALHAAGH GAGEPAQRGV RWLVDTQRPD
     GGWDEPHYTG TGFPGDFYIN YGMYRLVFPI SALGRILNAR GGLTAEVVP
//
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