ID   A0A1Q5AAT9_9ACTN        Unreviewed;      1404 AA.
AC   A0A1Q5AAT9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
GN   ORFNames=A6A27_30620 {ECO:0000313|EMBL:OKI56193.1};
OS   Micromonospora sp. CB01531.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1718947 {ECO:0000313|EMBL:OKI56193.1, ECO:0000313|Proteomes:UP000186700};
RN   [1] {ECO:0000313|EMBL:OKI56193.1, ECO:0000313|Proteomes:UP000186700}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01531 {ECO:0000313|EMBL:OKI56193.1,
RC   ECO:0000313|Proteomes:UP000186700};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKI56193.1}.
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DR   EMBL; LWLS01000085; OKI56193.1; -; Genomic_DNA.
DR   RefSeq; WP_073837228.1; NZ_LWLS01000085.1.
DR   STRING; 1718947.A6A27_30620; -.
DR   OrthoDB; 135105at2; -.
DR   Proteomes; UP000186700; Unassembled WGS sequence.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR025139; DUF4062.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004155; PBS_lyase_HEAT.
DR   PANTHER; PTHR12697:SF5; DEOXYHYPUSINE HYDROXYLASE; 1.
DR   PANTHER; PTHR12697; PBS LYASE HEAT-LIKE PROTEIN; 1.
DR   Pfam; PF13271; DUF4062; 1.
DR   Pfam; PF13646; HEAT_2; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   SMART; SM00567; EZ_HEAT; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186700}.
FT   DOMAIN          273..403
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   1404 AA;  155562 MW;  72173B323D8CDEB6 CRC64;
     MKVYISATQK DLLEYRAAVH AAARRLEIED VAMEAYGADI RPPLERCLAD VRRCDLYVGL
     FAWRYGFRPP GQESSITELE YREALAAGKP CLIFLLAEDT PWPVDMIDRD ADWQQIVALR
     RELKERHLCA FFSSVDDLSA KVTVALADVR SGRSPAREPA DPDTHLPDAV RNHYYKQLAL
     RYQAVPLDGV SPRPTIGYLT VGLPKVFVEP RVHEDARPEM PLAWWRWAGS TPDGDTGGLP
     GVVDPEEVER LWEEYAAKDA LALFDVVCDP SHRAIVLLGD PGSGKSATAR YLALALAGAC
     VEPRLAALDR YLPVLIELRS YAVHCGDGRC DGLLDYVGHR HQQGLAGIDQ DVLESYLRQG
     GQALFLFDGL DEVFDPAQRE EVAAQIATFA NEYPGVRTVV TSRAAGYLRH TFANAGFDHF
     TLEDLDDERI ARFLGNWYRY VMPTPAAEAD RQRRQILDVV RRSRAMHEIA GNPLLLMLMA
     IVGRGHPLPR NRRRLYAHVT DVLISEWDVT KQLRESHGDV PPLDPQAKRR LLRHLAFRMQ
     FRESGPAGNY IESDELARIF RDHLVDFYGF ENERALAMAY SMIDKLRQRS FILERYGLRL
     FGFVHRTFLE FFCAEEIVDR FEHDPDAWGL DQLRALFREH WADPSWREVL RLVASALPAP
     TANDLVTLLA TEVNQPWPPL NLTGPPWNLV LAAQCVAEAP QPAELAGAGN AVLGQIVLLV
     EHGISADDPN LVELTEQELL SSIRALGRHW PGRAAFLHWY RRRGVRTSWR SGSAFATRIA
     AVLSTAEEQL EELLVRELGQ GRERQAHLTM VAGLAEAAGR LDTTNPSRRR CRDLLLAQAQ
     AEVSTAVRQA AVRALVAHFS ADPELVDVLR DLTESPDPAV RALAVQSLGG RAELSEDVRQ
     VLARATEDPA TAVRRAAVGV LAARCADLPG VPETLQRLLD TDTDPAVVQR ALEGLLALPE
     RADTARTRAL ERVASDAPDE VRRGLVTELL PGGPSPDGTE LLLKLACSAS SARLRAVAVQ
     RLALVPDPEG RCRARLVDQI EQDEDASVRA AAVTALLEQD RADDSGWTVA AYAARADDDA
     TVRLAAVRAL AEAYPDHRTG ELLLERARRD PTASVRLAAV DLLTGRPLLG HATRDLLISR
     ASQERDPIVR LRVTRSLTHL GEPPDPEVRE CLAEQVSRDP DPNVLRAAAQ ALARHGQAGS
     LLETLCRRAR RDSYAGIRLA AVQALCAYGS PDVVTDVLLE CVESDTDPAV FDAAVRCLTE
     RGSASMAVTL RLMRRLADQD PAIRARIAAA LGEHFGADPE VRVLLVGLVR DDPDLEVRRR
     AVEQLGATLA DRMGVRELLL RLADDDDWEI RRTALLALTR HYRGDSRTRE VLVRLAHQED
     DGTVRRLAAQ LLASLPDTKP DDFP
//