ID A0A1Q5D861_9ACTN Unreviewed; 341 AA.
AC A0A1Q5D861;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:OKI91979.1};
GN ORFNames=AMK18_32400 {ECO:0000313|EMBL:OKI91979.1};
OS Streptomyces sp. CB01249.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKI91979.1, ECO:0000313|Proteomes:UP000186839};
RN [1] {ECO:0000313|EMBL:OKI91979.1, ECO:0000313|Proteomes:UP000186839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01249 {ECO:0000313|EMBL:OKI91979.1,
RC ECO:0000313|Proteomes:UP000186839};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. FabH family.
CC {ECO:0000256|ARBA:ARBA00008642}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI91979.1}.
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DR EMBL; LISW01000010; OKI91979.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q5D861; -.
DR Proteomes; UP000186839; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00827; init_cond_enzymes; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013751; ACP_syn_III_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR34069; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 3; 1.
DR PANTHER; PTHR34069:SF2; BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III; 1.
DR Pfam; PF08545; ACP_syn_III; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000186839}.
FT DOMAIN 108..181
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08545"
FT DOMAIN 246..337
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
SQ SEQUENCE 341 AA; 36387 MW; 3E249262B6B226CB CRC64;
MKVDNVYLAG IGSWIPDRVS VDEAIEKGWY DETLRASSGM VSVAVAGDVP APDMAIAAAE
EALKRSGHEP EEIAALIHTP VFHQGPDIWS APHYILHRTV NRPVPALELR QGCLGMITSL
RFAATMMTAD PAAGAVLITA GDNFSTPGLD RWRVSSNYVL GDAGSAVVLS RREGFAKLLS
VSSISIPEAE ILHRGGDPLF PPSITLGHPL DLEARTDHIR AQWIKGVPPP VFHLGDIVVE
AVTAALTDAG RTLDDITRVA HSAVAFDQIR NGFLEPLGIE ESRGTWEFNR RVGHSGGTDQ
IVGLEHLLAS GELRPGDHVL LLAAAVGMEV GCAVLEIVDI P
//
