ID A0A1Q5D935_9ACTN Unreviewed; 422 AA.
AC A0A1Q5D935;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Beta-ACP synthase {ECO:0000313|EMBL:OKI92342.1};
GN ORFNames=AMK10_21465 {ECO:0000313|EMBL:OKI92342.1};
OS Streptomyces sp. CB02058.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703921 {ECO:0000313|EMBL:OKI92342.1, ECO:0000313|Proteomes:UP000185610};
RN [1] {ECO:0000313|EMBL:OKI92342.1, ECO:0000313|Proteomes:UP000185610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02058 {ECO:0000313|EMBL:OKI92342.1,
RC ECO:0000313|Proteomes:UP000185610};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI92342.1}.
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DR EMBL; LIPG01000004; OKI92342.1; -; Genomic_DNA.
DR RefSeq; WP_073749549.1; NZ_LIPG01000004.1.
DR AlphaFoldDB; A0A1Q5D935; -.
DR OrthoDB; 9808669at2; -.
DR Proteomes; UP000185610; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 2..416
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 422 AA; 44088 MW; 2E55601F76D05073 CRC64;
MTRRVAVTGV GVVAPGGIGA PAFWDLLSNG RTATRGITLF DPAAFRSRIA AECDFDPVAY
GLDDELIARS DRYVQFALVA AREALGDAGL DMEKEDPWRV GVSLGTAVGG TTRLEHDYVA
VSGSGARWDV DHRPAGAHLE RAFSPSTLAS AVAEEVGAHG PVQTVSTGCT SGLDAIGYAF
QSVEEGRVDI CVAGASDTPI TPITVACFDA IKATSANNDD PEHASRPFDA RRDGFVMGEG
GAVLVLEELE HARARGATIY CEISGYATFG NAYHMTGLTS EGLEMAEAIN TALGHARLDG
SQVDYVNAHG SGTKQNDRHE TAAVKRALGA HAYKVPMSSI KSMVGHSLGA IGAIEIAACV
LALEHQTVPP TANYETADPE CDLDYVPRTA RPLKLRSVLS VGSGFGGFQS AVALTRSGGR
TP
//
