ID A0A1Q5DCS4_9ACTN Unreviewed; 849 AA.
AC A0A1Q5DCS4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Metallophosphoesterase {ECO:0000313|EMBL:OKI93662.1};
GN ORFNames=AMK10_14715 {ECO:0000313|EMBL:OKI93662.1};
OS Streptomyces sp. CB02058.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703921 {ECO:0000313|EMBL:OKI93662.1, ECO:0000313|Proteomes:UP000185610};
RN [1] {ECO:0000313|EMBL:OKI93662.1, ECO:0000313|Proteomes:UP000185610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02058 {ECO:0000313|EMBL:OKI93662.1,
RC ECO:0000313|Proteomes:UP000185610};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI93662.1}.
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DR EMBL; LIPG01000003; OKI93662.1; -; Genomic_DNA.
DR RefSeq; WP_073748250.1; NZ_LIPG01000003.1.
DR AlphaFoldDB; A0A1Q5DCS4; -.
DR OrthoDB; 9807890at2; -.
DR Proteomes; UP000185610; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd07423; MPP_Prp_like; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041780; MPP_PrpE-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR024028; PNKP_bac.
DR InterPro; IPR032380; PNKP_ligase_dom.
DR NCBIfam; TIGR04075; bacter_Pnkp; 1.
DR PANTHER; PTHR12435:SF2; PROTEIN KTI12 HOMOLOG; 1.
DR PANTHER; PTHR12435; UNCHARACTERIZED; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF16542; PNKP_ligase; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
FT DOMAIN 189..378
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 466..844
FT /note="Polynucleotide kinase-phosphatase ligase"
FT /evidence="ECO:0000259|Pfam:PF16542"
SQ SEQUENCE 849 AA; 93782 MW; E7738F159B7432B6 CRC64;
MTSTRTSRTL PVTDLSLVVL IGASGSGKST FARKHFKPTE VISSDFCRGL VADDENDQSA
SRDAFDVLHY IAGKRLAAGR LTVVDATNVQ PESRRQLVQL ARQYDVLPIA IVLDLPEELC
QARNAERPDR AGMPRHVVQR HRRELRRSLR GLEREGFRKV HILRSEEEAD SAEVVLERRY
NDLRHLTGPF DIIGDIHGCS SELDTLLGRL GYKDGAHPEG RTAVFVGDLV DRGPDSPGVL
RRVMSMVAEG NALCVPGNHE NKLGRYLKGR KVQHTHGLAE TIEQLEREDA HDPEFRKRVA
EFIDGLVSHY VLDDGKLVVC HAGLPEKYHG RTSGRVRSHA LYGETTGETD EFGLPVRYPW
AEDYRGSAAV VYGHTPVPTA SWVNNTLCLD TGAVFGGRMT ALRWPEREMV DVPAEQVWYE
PVKPLTTEAP GGREGRPLDL ADVQGRRIVE TRHMGRVAVR EENAAAALEV MSRFAVDPRL
LAYLPPTMAP TATSHEEGFL EHPAEAFAQY RADGVTKVVC EEKHMGSRAV ALVCRDAAAA
RERFGADGPT GVLHTRTGRP FLDDPALTEV VLGRLRTALT AAGLWDEWET DWVLLDAELM
PWSLKAAGLL RSQYAAVGAA AGAVLPVAED ALSAAAARGV DVGALAGRQR ERAADATAFT
EAYRRYCWST EGLDGVRLAP FQILAVQGRS LAAVPHDEQL AWLDRLVEHD PTGLLQVTRR
LVVDTGDEAS VRSGIDWWLE MTGRGGEGMV VKPLAALVRD DKGRLVQPGI KVRGREYLRI
IYGPEYTRPE NLDRLRSRFL GHKRSLALRE YALGLEALDR LAEGEPLWRV HEAVFAVLAL
ESEPVDPRL
//
