ID   A0A1Q5DQ79_9ACTN        Unreviewed;       252 AA.
AC   A0A1Q5DQ79;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=IclR family transcriptional regulator {ECO:0000313|EMBL:OKI97917.1};
GN   ORFNames=AMK10_03620 {ECO:0000313|EMBL:OKI97917.1};
OS   Streptomyces sp. CB02058.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703921 {ECO:0000313|EMBL:OKI97917.1, ECO:0000313|Proteomes:UP000185610};
RN   [1] {ECO:0000313|EMBL:OKI97917.1, ECO:0000313|Proteomes:UP000185610}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02058 {ECO:0000313|EMBL:OKI97917.1,
RC   ECO:0000313|Proteomes:UP000185610};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKI97917.1}.
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DR   EMBL; LIPG01000001; OKI97917.1; -; Genomic_DNA.
DR   RefSeq; WP_073744643.1; NZ_LIPG01000001.1.
DR   AlphaFoldDB; A0A1Q5DQ79; -.
DR   OrthoDB; 9807558at2; -.
DR   Proteomes; UP000185610; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR   PANTHER; PTHR30136:SF24; HTH-TYPE TRANSCRIPTIONAL REPRESSOR ALLR; 1.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   4: Predicted;
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          2..61
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51077"
FT   DOMAIN          62..245
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000259|PROSITE:PS51078"
SQ   SEQUENCE   252 AA;  27710 MW;  93A0071883B7A2AF CRC64;
     MSQTVDRALS ILPLLAQGPA DLGQVAERLG VHKSTALRLL RTLHEHGLVY RQEDQRYRLG
     ARLFALAQEA VENLDVREIA HSHLVTLNEQ CGHTVHLAVY EENEVLYIDK VESRYPVRMY
     SRIGKPVAIT VAAVAKLLLA DLTEPERRAV AERLDYPMYT SRSVPNAGAF LKELAVVREQ
     GWATDLGGHE ESINCVGAPI RGADGRVVAA MSVSAPNVVV TAEELLTLLP LVRRTADTIS
     REYSGTTPTK KA
//