ID A0A1Q5DUM4_9ACTN Unreviewed; 943 AA.
AC A0A1Q5DUM4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=AfsR family transcriptional regulator {ECO:0000313|EMBL:OKI99529.1};
GN ORFNames=AMK18_20725 {ECO:0000313|EMBL:OKI99529.1};
OS Streptomyces sp. CB01249.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKI99529.1, ECO:0000313|Proteomes:UP000186839};
RN [1] {ECO:0000313|EMBL:OKI99529.1, ECO:0000313|Proteomes:UP000186839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01249 {ECO:0000313|EMBL:OKI99529.1,
RC ECO:0000313|Proteomes:UP000186839};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI99529.1}.
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DR EMBL; LISW01000004; OKI99529.1; -; Genomic_DNA.
DR RefSeq; WP_073863919.1; NZ_LISW01000004.1.
DR AlphaFoldDB; A0A1Q5DUM4; -.
DR OrthoDB; 581105at2; -.
DR Proteomes; UP000186839; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF13424; TPR_12; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000186839};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..96
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 1..96
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 247..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 943 AA; 99529 MW; 37D1616C947A2C24 CRC64;
MEFRLLGTVC VDTLTGPLPL GPAKRRSLLA ALLLHANTPV SMARLTDCLW DEEPPLHART
VIQGHVSRLR ALLVGADAQA YGVELATLGD AYVLRAPETL LDSQRFEELL MLAREQRDPA
DTVLMLKEAL SLWQGPALTG TFASAPLQAA AHALEESRLS TVEQLARAYG ELGEHHRAAA
VLRVEAVAHP LRESLAAALM TALHRSGRQS EALDCFHRTR RLLADELGID PGRELADAYA
RILRGEGGGG PVAPGDTAEA AGPPVHGGGP AAPHASGGTQ VIAPRAAVAP VHAPPAPYAA
AGAPAPVADL LPRAPRGFHG RGTELTALSR AAAGEAPVCL VTGPAGVGKT ALALHWARRT
PAAFPDGRLF ADLRGFGDTA EPTPLEVLRE FLLALGVAPR RVPESMAGAA ALFRSLTDRL
SLLVVLDNAR DSAQVRPLLP GGADCVTLVT SRHRLDGLIA SDAAVPVPVD ILEPTDGTAL
LAGVLGEERV LAEPVAARRL AELCGGLPLA LRVTAARLAG RPQWTLAAMA EELADERSRL
SYLDVEDTGV SAALRLTVQQ LPPDAVHHLG RLGHHPGSHF DPYTAAALAG SDPVTAGAAL
ERLAAAHLVT EAGPGRWILH DLVRLYARGL DPAAAPDALI GVLDHYIATA LAAADTAEPG
GEPCFVLPAD FHAPTATRDF TDRAEAMSWL AAEREDLTLA AAAARAAGLD DRAWRIILLQ
WPHVVWRVRD GWTPMLDLAL AAAVAREDPY AESRVRNLLG WVLTEEGRTG EAVAMLEPSP
GLARQAGDRL GEATALINLA IVQAEQGGLD VAMEGCERAL ELAREEPDAH TEMLALQHLA
RMQLTAGRPQ DALDSARTAF DLGPEHEEAA RRVLLLSVSG EARLALGAEE EGIRLLDEAA
AEAERAGYDE GAVRALEALL RVTASPDHVR RRTEATRRLT ADG
//
