ID A0A1Q5DUM5_9ACTN Unreviewed; 373 AA.
AC A0A1Q5DUM5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=MerR family transcriptional regulator {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMK18_20810 {ECO:0000313|EMBL:OKI99544.1};
OS Streptomyces sp. CB01249.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKI99544.1, ECO:0000313|Proteomes:UP000186839};
RN [1] {ECO:0000313|EMBL:OKI99544.1, ECO:0000313|Proteomes:UP000186839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01249 {ECO:0000313|EMBL:OKI99544.1,
RC ECO:0000313|Proteomes:UP000186839};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKI99544.1}.
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DR EMBL; LISW01000004; OKI99544.1; -; Genomic_DNA.
DR RefSeq; WP_073863930.1; NZ_LISW01000004.1.
DR AlphaFoldDB; A0A1Q5DUM5; -.
DR OrthoDB; 9801841at2; -.
DR Proteomes; UP000186839; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01107; HTH_BmrR; 1.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR30204:SF96; MERR FAMILY REGULATORY PROTEIN; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF13411; MerR_1; 1.
DR Pfam; PF13672; PP2C_2; 1.
DR SMART; SM00422; HTH_MERR; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000186839}.
FT DOMAIN 19..89
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
FT DOMAIN 138..370
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
SQ SEQUENCE 373 AA; 38736 MW; EFDE54550CE33559 CRC64;
MRRRAVTEYG QGRGPGAELV TIGAFARLSR LSAKALRRYD ELGLLPPALV DPVNGYRYYD
PAQVRAARLV AWLRRIGMPL ARIREVIALD SGAAAAAIRA YWARVEAETA ARRDLAAFLI
DQLSTEDVMT SVGTLGIRYA ARTATGAVRE TNQDAVYAGA RLLAVADGFG AGGAGASTAA
IEALKPVVPG AVPAGELLNV LHDAAERAAL AVRDAVAGGA APEESGTTLT AMMWTGSRLG
LVHIGDSRAY LLRGGELFRI THDHSLVQSM IDDGSLTEEE AFSHPQRAML LKVLSGDGPY
GSGPDVDVRD ALPGDRYLLC SDGLSAVVDG GELARVLAGA DGPSTAVGGL IELAEAAGAP
DNVACAVADV VEL
//
