ID A0A1Q5DWW3_9ACTN Unreviewed; 339 AA.
AC A0A1Q5DWW3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=NADP-dependent oxidoreductase {ECO:0000313|EMBL:OKJ00334.1};
GN ORFNames=AMK18_16895 {ECO:0000313|EMBL:OKJ00334.1};
OS Streptomyces sp. CB01249.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKJ00334.1, ECO:0000313|Proteomes:UP000186839};
RN [1] {ECO:0000313|EMBL:OKJ00334.1, ECO:0000313|Proteomes:UP000186839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01249 {ECO:0000313|EMBL:OKJ00334.1,
RC ECO:0000313|Proteomes:UP000186839};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ00334.1}.
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DR EMBL; LISW01000003; OKJ00334.1; -; Genomic_DNA.
DR RefSeq; WP_073863446.1; NZ_LISW01000003.1.
DR AlphaFoldDB; A0A1Q5DWW3; -.
DR OrthoDB; 9805663at2; -.
DR Proteomes; UP000186839; Unassembled WGS sequence.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05288; PGDH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR041694; ADH_N_2.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR045010; MDR_fam.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR Pfam; PF16884; ADH_N_2; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000186839}.
FT DOMAIN 23..336
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 339 AA; 35827 MW; F07C8C96609A9AB8 CRC64;
MSAALPASGR EWHLTARPHG WPKAEDFALR EAPVAAPAEG RVLVRNLHFS VDPYMRGRMN
DVKSYTPPFK LDHPMDGGAV GEVVASNAEG FQVGDHVLHG LGWREYASVP AKHAVKVDGS
LAPLSAYLGV LGMPGLTAYA GLFDVASFKE GDAVFVSGAA GAVGSQVGQM AKIKGASRVI
GSAGSDEKVK LLTEEYGFDA AFNYKNGPVK EQLAAAAPDG IDVYFDNVGG EHLEAALSSF
NVHGRATICG MIAQYNATEP TPAPRNLALV IGKRLRLQGM LVGDHADLQQ QFVQDVAGWL
ASGELKYRET VVEGIENGVD AFLGLLRGEN TGKMIVSLG
//