ID   A0A1Q5E173_9ACTN        Unreviewed;       560 AA.
AC   A0A1Q5E173;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Kinase {ECO:0000313|EMBL:OKJ01854.1};
GN   ORFNames=AMK18_10535 {ECO:0000313|EMBL:OKJ01854.1};
OS   Streptomyces sp. CB01249.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKJ01854.1, ECO:0000313|Proteomes:UP000186839};
RN   [1] {ECO:0000313|EMBL:OKJ01854.1, ECO:0000313|Proteomes:UP000186839}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01249 {ECO:0000313|EMBL:OKJ01854.1,
RC   ECO:0000313|Proteomes:UP000186839};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKJ01854.1}.
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DR   EMBL; LISW01000002; OKJ01854.1; -; Genomic_DNA.
DR   RefSeq; WP_073862632.1; NZ_LISW01000002.1.
DR   AlphaFoldDB; A0A1Q5E173; -.
DR   OrthoDB; 255834at2; -.
DR   Proteomes; UP000186839; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR021122; RNA_ligase_dom_REL/Rnl2.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF09414; RNA_ligase; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:OKJ01854.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186839};
KW   Transferase {ECO:0000313|EMBL:OKJ01854.1}.
FT   DOMAIN          34..182
FT                   /note="RNA ligase"
FT                   /evidence="ECO:0000259|Pfam:PF09414"
SQ   SEQUENCE   560 AA;  59688 MW;  82AF1398E22285A1 CRC64;
     MRTHYPRTAH LPWSPGATSD DVRMTDLAAL AGTEVVVTEK LDGENTTLYA DGLHARSLDS
     AHHPSRTWVK ALQARVGARI PQGWRICGEN MFARHSLAYD ALESHFYGFS VWDGDRCLGW
     DRTVEFLRSL GIPAPPVLWR GVFDAKALRA VKPDTGRQEG YVVRPAASFP AALFGRVVGK
     WVRPGHVVTD THWMHAEVVE NGLGAGAALW AVRSGAPVDA GALRAAVGAG PEAGPEPEGG
     PERALAAVDA LDALGRTGDD RLAGVLAALL HGTRRPALAP LLAPALGMPL ARRVADLVGL
     APGLHQPYPD EERRAGLARM ALAADLSVLH AVSGALADTA EAREQVEWSA LHAAEVREPD
     GLAEAFADLG PEAAARCLAQ AREAYADGRI ATAEEAVAAT WRWRSGDFPR LVQLAGPSGS
     GKSTFGRGLP GVATYISLDD LRLARGSRAD QSANGDVLRE GLDRLDAALV PGATVVWDAT
     SLNPHQRSLV HAVARRRDAL VTHAVAWIGE AELAARNGRR EHPVPPQVLA SQLHRFVPPY
     PGQAHRTWYI GTSGTVEDRA
//