ID A0A1Q5E2K7_9ACTN Unreviewed; 459 AA.
AC A0A1Q5E2K7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Metal-dependent phosphohydrolase {ECO:0000313|EMBL:OKJ02321.1};
GN ORFNames=AMK18_13040 {ECO:0000313|EMBL:OKJ02321.1};
OS Streptomyces sp. CB01249.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKJ02321.1, ECO:0000313|Proteomes:UP000186839};
RN [1] {ECO:0000313|EMBL:OKJ02321.1, ECO:0000313|Proteomes:UP000186839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01249 {ECO:0000313|EMBL:OKJ02321.1,
RC ECO:0000313|Proteomes:UP000186839};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ02321.1}.
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DR EMBL; LISW01000002; OKJ02321.1; -; Genomic_DNA.
DR RefSeq; WP_073862928.1; NZ_LISW01000002.1.
DR AlphaFoldDB; A0A1Q5E2K7; -.
DR OrthoDB; 9802066at2; -.
DR Proteomes; UP000186839; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR037522; HD_GYP_dom.
DR InterPro; IPR006675; HDIG_dom.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1.
DR PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR Pfam; PF13487; HD_5; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51832; HD_GYP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:OKJ02321.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186839};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 227..422
FT /note="HD-GYP"
FT /evidence="ECO:0000259|PROSITE:PS51832"
FT DOMAIN 249..371
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 422..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 48544 MW; 6BE2E77022326E96 CRC64;
MRATRGAARA HIGAVALGAA LCAAPALRPG TPWTTLALLA GLYLACELLG RRPFPVGAVG
AGSFFPLLLA AAFLLPPAAA ALVAVPGSLA GRAGKPPAAA RRIWRAAEPA LAVWAAARVH
ALLGGPAALG SPPDLPYALL PVCAAALAFS AVLAALDGSI LVAAEQLPVR RAWRGLLPRS
LAPHLVHGLA GLMMAVLWNS SYGPLAALFV LLPMYISCWV YAQYHREHAA HRATIRALVQ
AVDIKDTYTR GHSERVGRAS VLIAHELGLD RERVEVLRFA GILHDVGKLG VPTRVLRKDG
PLTPEERRVI ELHPEYGHEI VRGIGFLGEA RAAILHHHER LDGSGYPYGL SGRGIPECAR
IVAVADAFDA MTSTRSYRRG RPVPVAVEEL KRCAGTQFDP QMVRALARGL ERYGWFGAVT
ADDAQLPPPR EEDAGRGVGA GALNAPLTPR PPDATEGPR
//
