ID   A0A1Q5E865_9ACTN        Unreviewed;       393 AA.
AC   A0A1Q5E865;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=ROK family transcriptional regulator {ECO:0000313|EMBL:OKJ04324.1};
GN   ORFNames=AMK18_03850 {ECO:0000313|EMBL:OKJ04324.1};
OS   Streptomyces sp. CB01249.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKJ04324.1, ECO:0000313|Proteomes:UP000186839};
RN   [1] {ECO:0000313|EMBL:OKJ04324.1, ECO:0000313|Proteomes:UP000186839}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01249 {ECO:0000313|EMBL:OKJ04324.1,
RC   ECO:0000313|Proteomes:UP000186839};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family.
CC       {ECO:0000256|ARBA:ARBA00006479}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKJ04324.1}.
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DR   EMBL; LISW01000001; OKJ04324.1; -; Genomic_DNA.
DR   RefSeq; WP_018100298.1; NZ_LISW01000001.1.
DR   AlphaFoldDB; A0A1Q5E865; -.
DR   OrthoDB; 3189808at2; -.
DR   Proteomes; UP000186839; Unassembled WGS sequence.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR   PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186839}.
SQ   SEQUENCE   393 AA;  39988 MW;  055C32240AD0004E CRC64;
     MTARPANAHQ AQLLKLLRDG GPNSRAKLGD QVDLSRSKLA VEVDRLLETG LVVADGLAAS
     RGGRRSHNIR LAPHLRFLGV DIGATSVDVA VTNAELEVLG HLNHPMDVRE GPVAVFEQVL
     SMAAKLRDSG LADSFDGAGI GVPGPVRFPE GVPVAPPIMP GWDGFPVREA LSQELGCPVM
     VDNDVNLMAL GEQQAGVARS VGDFLCVKIG TGIGCGIVVG GTVHRGATGS AGDIGHIQVE
     PGGRLCACGN KGCLEAHFSG AALARDAEDA ARAGRSEELA ARLEASGRLT AADVAAAAAA
     GDATSLLLIR EGGNHVGQVI AGLVSFFNPA LVVIGGGVTG LGHTLLAAVR AQVYRRSLPL
     ATGNLPIVLG ELGPAAGVTG AARLISDHLF SPV
//