ID   A0A1Q5E8U3_9ACTN        Unreviewed;       441 AA.
AC   A0A1Q5E8U3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Carboxypeptidase {ECO:0000313|EMBL:OKJ04435.1};
GN   ORFNames=AMK18_04425 {ECO:0000313|EMBL:OKJ04435.1};
OS   Streptomyces sp. CB01249.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKJ04435.1, ECO:0000313|Proteomes:UP000186839};
RN   [1] {ECO:0000313|EMBL:OKJ04435.1, ECO:0000313|Proteomes:UP000186839}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01249 {ECO:0000313|EMBL:OKJ04435.1,
RC   ECO:0000313|Proteomes:UP000186839};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M14 family.
CC       {ECO:0000256|ARBA:ARBA00005988}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKJ04435.1}.
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DR   EMBL; LISW01000001; OKJ04435.1; -; Genomic_DNA.
DR   RefSeq; WP_073861712.1; NZ_LISW01000001.1.
DR   AlphaFoldDB; A0A1Q5E8U3; -.
DR   OrthoDB; 9758209at2; -.
DR   Proteomes; UP000186839; Unassembled WGS sequence.
DR   GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd06242; M14-like; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR000834; Peptidase_M14.
DR   PANTHER; PTHR11705:SF91; CARBOXYPEPTIDASE A1 (PANCREATIC)-RELATED; 1.
DR   PANTHER; PTHR11705; PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B; 1.
DR   Pfam; PF00246; Peptidase_M14; 1.
DR   SMART; SM00631; Zn_pept; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000313|EMBL:OKJ04435.1};
KW   Hydrolase {ECO:0000313|EMBL:OKJ04435.1};
KW   Protease {ECO:0000313|EMBL:OKJ04435.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186839}.
FT   DOMAIN          59..286
FT                   /note="Peptidase M14 carboxypeptidase A"
FT                   /evidence="ECO:0000259|SMART:SM00631"
SQ   SEQUENCE   441 AA;  46940 MW;  8533B15A54387961 CRC64;
     MPIAPTAGGR RLPRRGRARD LALAVVSAAL TVPLLSVPSD AARTAAPRTG FEVSGGARWT
     RQSEEASLLA GLARRGDRVS VRRIGTTAQG RPLRLVRIGS TEPDALTVLL VCGQHGDEPA
     AREACLSTVR DLAYATDART RALLARTEVL VVPTANPDGL AAGTRTNGDG VDINRDHLAL
     RSPEARAVAA VLRDHEPDVI EDLHEYPATA PYYDKDLLVL WPRNPNTDPR LHDEARALAL
     DRVRPAAGKA GFGTGLYGVW TDPATGHPVK RTAGDGQERI LRNIAGLTHA VGLLAESRTD
     ALSAEERADP ALNARRRVTS QLVVLKALFR YADEQRAGIA AATAASRAAG ADDRGPVFLG
     GSDDEAPARG DTLADPPCGY RLTREQFARV GDELALHAVT SRPDGDGVYV PLRQPARKLI
     PLLLDVRAAY HLTNGQPDTA C
//