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Database: UniProt
Entry: A0A1Q5E974_9ACTN
LinkDB: A0A1Q5E974_9ACTN
Original site: A0A1Q5E974_9ACTN 
ID   A0A1Q5E974_9ACTN        Unreviewed;       543 AA.
AC   A0A1Q5E974;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-JUN-2019, entry version 9.
DE   SubName: Full=Histidine kinase {ECO:0000313|EMBL:OKJ04622.1};
GN   ORFNames=AMK18_05435 {ECO:0000313|EMBL:OKJ04622.1};
OS   Streptomyces sp. CB01249.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKJ04622.1, ECO:0000313|Proteomes:UP000186839};
RN   [1] {ECO:0000313|EMBL:OKJ04622.1, ECO:0000313|Proteomes:UP000186839}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01249 {ECO:0000313|EMBL:OKJ04622.1,
RC   ECO:0000313|Proteomes:UP000186839};
RX   PubMed=27999165;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural
RT   Products.";
RL   MBio 7:e02104-16(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OKJ04622.1}.
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DR   EMBL; LISW01000001; OKJ04622.1; -; Genomic_DNA.
DR   RefSeq; WP_073861851.1; NZ_LISW01000001.1.
DR   Proteomes; UP000186839; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000186839};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:OKJ04622.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186839};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     24     50       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    221       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      223    276       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      305    520       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   REGION      512    543       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1Q5E974}.
SQ   SEQUENCE   543 AA;  59766 MW;  4D5721210AE830EB CRC64;
     MSSEIPDPVV QPAGRWARLS VQNWVHLILG AFVLVVCGCV VAGGLVLAGI SDRTTELVDR
     IQPARSASFQ LQNALLNQET GVRGYVLTGD DSFLEPFAAG KKEETDRLAR VRSAMGGEQP
     YSRDLDRIAA AAAEWRRVHA DPLIADVRRD GPGARSAAGT AESKAAFDKL RQLYGTQQAH
     LDDARDRVRG ELDDARHTRD RVLTALLVVF ALCVIALSML LQRTVGRPLN ALAEASRRVR
     SSSFRRQRIE VRGPADVRAV AAAVEDMRGR LVAELDAVQE REDVLAQQTV ELRRSNSELE
     QFAYVASHDL QEPLRKVASF CQLLDKRYGN ELDGRGKQYI DFAVDGAKRM QVLINDLLTF
     SRVGRVHDSW TPVELDRSLD RALANLGMVI EESGTTVVRE DPLPSVTGDP TTLAMIWQNL
     IGNAVKFRRA DEPCVITVGC EREGDDWHFT VADNGIGIAP EFAEKVFVIF QRLHARDEYD
     GTGIGLALCR KIIEFHGGRI WLDPDSRQGA RVHFSLPADP EPEPEPAETN DAAAPAEISG
     ATT
//
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