GenomeNet

Database: UniProt
Entry: A0A1Q5E978_9ACTN
LinkDB: A0A1Q5E978_9ACTN
Original site: A0A1Q5E978_9ACTN 
ID   A0A1Q5E978_9ACTN        Unreviewed;       158 AA.
AC   A0A1Q5E978;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   31-JUL-2019, entry version 9.
DE   RecName: Full=Urease {ECO:0000256|SAAS:SAAS00779074};
DE            EC=3.5.1.5 {ECO:0000256|SAAS:SAAS00779074};
GN   ORFNames=AMK18_05480 {ECO:0000313|EMBL:OKJ04631.1};
OS   Streptomyces sp. CB01249.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1703929 {ECO:0000313|EMBL:OKJ04631.1, ECO:0000313|Proteomes:UP000186839};
RN   [1] {ECO:0000313|EMBL:OKJ04631.1, ECO:0000313|Proteomes:UP000186839}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01249 {ECO:0000313|EMBL:OKJ04631.1,
RC   ECO:0000313|Proteomes:UP000186839};
RX   PubMed=27999165;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural
RT   Products.";
RL   MBio 7:e02104-16(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+);
CC         Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938;
CC         EC=3.5.1.5; Evidence={ECO:0000256|SAAS:SAAS01115728};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3)
CC       from urea (urease route): step 1/1.
CC       {ECO:0000256|SAAS:SAAS00779045}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC
CC       (alpha) subunits. Three heterotrimers associate to form the active
CC       enzyme. {ECO:0000256|SAAS:SAAS00779069}.
CC   -!- SIMILARITY: Belongs to the urease beta subunit family.
CC       {ECO:0000256|SAAS:SAAS00779065}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OKJ04631.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; LISW01000001; OKJ04631.1; -; Genomic_DNA.
DR   RefSeq; WP_073861857.1; NZ_LISW01000001.1.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000186839; Unassembled WGS sequence.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-EC.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00407; Urease_beta; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   Pfam; PF00699; Urease_beta; 1.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000186839};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00779062};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186839}.
FT   REGION      120    158       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    144    158       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   158 AA;  16664 MW;  F5BCF5D14D02F4FF CRC64;
     MTFRQQYLYG DDPIELNAGR RTVKVTVSNT GDRAVQVGSH YHFFEVNSAL SFDREATLGT
     HLNIAAGTSV RFEPGGTREV ELCAYAGTGR LTGFSGLLNG SLASHPARVE AVRKAIERGF
     QGARNMPAGT GSKTGSKASG KDGAKGSKAA KDKKKGSL
//
DBGET integrated database retrieval system