ID A0A1Q5G280_9ACTN Unreviewed; 965 AA.
AC A0A1Q5G280;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=AfsR family transcriptional regulator {ECO:0000313|EMBL:OKJ26711.1};
GN ORFNames=AMK22_30435 {ECO:0000313|EMBL:OKJ26711.1};
OS Streptomyces sp. CB01580.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703933 {ECO:0000313|EMBL:OKJ26711.1, ECO:0000313|Proteomes:UP000186318};
RN [1] {ECO:0000313|EMBL:OKJ26711.1, ECO:0000313|Proteomes:UP000186318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01580 {ECO:0000313|EMBL:OKJ26711.1,
RC ECO:0000313|Proteomes:UP000186318};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ26711.1}.
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DR EMBL; LIXJ01000032; OKJ26711.1; -; Genomic_DNA.
DR RefSeq; WP_073790630.1; NZ_LIXJ01000032.1.
DR AlphaFoldDB; A0A1Q5G280; -.
DR STRING; 1703933.AMK22_30435; -.
DR OrthoDB; 581105at2; -.
DR Proteomes; UP000186318; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF03704; BTAD; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000186318};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 101..243
FT /note="Bacterial transcriptional activator"
FT /evidence="ECO:0000259|SMART:SM01043"
FT REGION 246..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 965 AA; 102515 MW; 270E1024821CED71 CRC64;
MEFRLLGTVS VETLTGPLPL GPAKRRSLLA ALLLSANTPV SMARLTDSLW DDAPPLHARG
VIQGHVSRLR ALLVGADAGA YGVELVTLGD AYLLRLSESL LDTHRFEELL LLAREQRDPA
DSVLMLKEAL SLWQGPALTG VFAAPPLQAA AHSLEESRLA TVEQLAYAYG VLGEHSRAAA
VLRTEAAAHP MRESLAAALM TALYRAGRQS EALDWFHRTR RLLAEELGID PGHELADAYA
LILRGDPGPE RAAEPDRTAG GAGGTNRTAG TDRTDEAHHA PARTDHAVRT NRAGGPGLAG
GPGRAAVASP PHASTAPTLA LSAGEPRPAD LLPRAPRGFQ GRAAELAALG RAAAGEAPVC
LVTGPAGVGK TALALHWAHR NAAAFPDGRL FADLRGFSDT GEPAPVEVLR EFLLALGVAP
RRVPESVSAA AALFRSLTDR RRLLVVLDNA RDSASVRPLL PGGADCVTLV TSRNRLEGLI
ASDAARPVPV DVLEPQDGTA LLAGVLGEER VLAEPMAARR LAELCGGLPL ALRVTAARLA
GRPRWTLAGL ADELADERSR LTYLDVDDTG VPAALRLTVQ QLSPDAVHQF TRLGHHPGSH
FDPYTAAALA GTNPVTAAAA LERLATAHLV TETAPGRWIL HDLVRLYARG LDPASADEAL
RNVLDHYIAT ALAAADTAEP GGEPCFVLPE DFRAPAAVRD FADRATAMRW LAAERDDLAL
AAVAARTAGL HDRAWRIILL QWPQVVWRVR DNWSPLLELA LGSARAEKDP YAESRVLNLL
GWVLTEEGRT SEAIALLERS PGLARQAGDR LGEATALVNL AVVQAEDGGL DAALVDCARA
VDLAREEGDT HTEMLALQHL ARMQLTANRP QDALDSARAA LALGPEQEEE ARRVLLLTVG
GEARLALGDE EAGIRMLDLA AAEAERTGYD QGAVRALEAL LRVTARAEYR RRYEEAVGRL
AVDDD
//
