ID A0A1Q5G2C2_9ACTN Unreviewed; 373 AA.
AC A0A1Q5G2C2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Protein-L-isoaspartate O-methyltransferase {ECO:0000256|ARBA:ARBA00013346};
DE EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
DE AltName: Full=L-isoaspartyl protein carboxyl methyltransferase {ECO:0000256|ARBA:ARBA00031350};
DE AltName: Full=Protein L-isoaspartyl methyltransferase {ECO:0000256|ARBA:ARBA00030757};
DE AltName: Full=Protein-beta-aspartate methyltransferase {ECO:0000256|ARBA:ARBA00031323};
GN ORFNames=AMK22_30495 {ECO:0000313|EMBL:OKJ26720.1};
OS Streptomyces sp. CB01580.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703933 {ECO:0000313|EMBL:OKJ26720.1, ECO:0000313|Proteomes:UP000186318};
RN [1] {ECO:0000313|EMBL:OKJ26720.1, ECO:0000313|Proteomes:UP000186318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01580 {ECO:0000313|EMBL:OKJ26720.1,
RC ECO:0000313|Proteomes:UP000186318};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ26720.1}.
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DR EMBL; LIXJ01000032; OKJ26720.1; -; Genomic_DNA.
DR RefSeq; WP_073790646.1; NZ_LIXJ01000032.1.
DR AlphaFoldDB; A0A1Q5G2C2; -.
DR STRING; 1703933.AMK22_30495; -.
DR OrthoDB; 5143400at2; -.
DR Proteomes; UP000186318; Unassembled WGS sequence.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR026448; Methyltr_grasp.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR04188; methyltr_grsp; 1.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF0; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR Pfam; PF01135; PCMT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:OKJ26720.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186318};
KW Transferase {ECO:0000313|EMBL:OKJ26720.1}.
SQ SEQUENCE 373 AA; 39926 MW; 49D9AE0C94B7DF1F CRC64;
MSDPLPSEHL QADLARRLSE AGALRSPEWE AAVLSVPREA FLSRGWFEYE EGGWYRPAAG
DSAEGLARIY EDDTLVTQVA GGVFPDQVEG RIAAAPSSSS TLPSLVVRML EDLRATEGTR
VLEIGTGTGY STALLCHVVG EDNVTTVEVD AEVSARAGIA LAGVGYWPVR VVGDGLAGCK
EGGPYDRVIA TCGVHTVPAA WLAQTRPGGE VLVTVGGWMH ASELVRLTVA DDGTASGPVL
GRRVSFMLAR PHLPPPLGIL PNLCEGDAVP TELGADVLDD WTARFVAQFA APRAQRVTVE
CDGRTEHVVI DVDAETWAVV FQDGARWMVR QGGTARLWDE ITERLAQWQA DGCPSADRMR
LHVGPDGQRP TWA
//
