ID A0A1Q5GHF3_9ACTN Unreviewed; 581 AA.
AC A0A1Q5GHF3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Precorrin methylase {ECO:0000313|EMBL:OKJ32041.1};
GN ORFNames=AMK22_24090 {ECO:0000313|EMBL:OKJ32041.1};
OS Streptomyces sp. CB01580.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703933 {ECO:0000313|EMBL:OKJ32041.1, ECO:0000313|Proteomes:UP000186318};
RN [1] {ECO:0000313|EMBL:OKJ32041.1, ECO:0000313|Proteomes:UP000186318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01580 {ECO:0000313|EMBL:OKJ32041.1,
RC ECO:0000313|Proteomes:UP000186318};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ32041.1}.
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DR EMBL; LIXJ01000019; OKJ32041.1; -; Genomic_DNA.
DR RefSeq; WP_073788463.1; NZ_LIXJ01000019.1.
DR AlphaFoldDB; A0A1Q5GHF3; -.
DR STRING; 1703933.AMK22_24090; -.
DR OrthoDB; 9804789at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000186318; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR Gene3D; 3.40.50.11220; -; 1.
DR Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR021744; CbiG_N.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR002750; CobE/GbiG_C.
DR InterPro; IPR036518; CobE/GbiG_C_sf.
DR InterPro; IPR038029; GbiG_N_sf.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF01890; CbiG_C; 1.
DR Pfam; PF11760; CbiG_N; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OKJ32041.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186318};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 37..116
FT /note="Cobalamin synthesis G N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11760"
FT DOMAIN 200..324
FT /note="CobE/GbiG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01890"
FT DOMAIN 332..537
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 581 AA; 58971 MW; D380E8FCE39D36BA CRC64;
MIGLISATAA GAAARDRLAA AWPGRAVVYE GPVRAAVHRA FAECEQLVCF LATGAVVRLL
APLLSDKSAD PGVVCVDEAG RHAVALLGGH AGGANALAEA VAEVLDATPV VTTATDAAGL
LGLDMLGLPV EGDVAGVSRA MLDGAPVELR ADALWPLPAL PPNVAPGSTL PDPADAAVLH
ITDRVVESGA RRAVVRPASL AVGVGASRGA PVDEVVGLVH DALREAGLSP LSIAELVTVD
AKADEPGIVA AAARLGVPLR TYAAEALARV EVPNPSGAPL AAVGTPSVAE AAALVEGGEL
LVPKRKSTPP PGSEGRAAMA TCAVVRRAPR GRLAVVGLGP GARDLLTPRA REELRRASVL
VGLDQYVDQI RDLLRPGTTV LESGLGAEEE RARTAVAEAR EGRAVALIGS GDAGVYAMAS
PALAEAGADI DVVGVPGVTA ALAAAAVLGA PLGHDHVSIS LSDLHTPWEV IERRVRAAAE
ADIVVTFYNP RSRGRAWQLP EALSILAEHR DPATPVGVVR NASRPDESAR VTSLAALDPA
AVDMMTVVTV GNTATRQIAG RMVTPRGYRW QSAAGTGEGG R
//