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Database: UniProt
Entry: A0A1Q5GHF3_9ACTN
LinkDB: A0A1Q5GHF3_9ACTN
Original site: A0A1Q5GHF3_9ACTN 
ID   A0A1Q5GHF3_9ACTN        Unreviewed;       581 AA.
AC   A0A1Q5GHF3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Precorrin methylase {ECO:0000313|EMBL:OKJ32041.1};
GN   ORFNames=AMK22_24090 {ECO:0000313|EMBL:OKJ32041.1};
OS   Streptomyces sp. CB01580.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703933 {ECO:0000313|EMBL:OKJ32041.1, ECO:0000313|Proteomes:UP000186318};
RN   [1] {ECO:0000313|EMBL:OKJ32041.1, ECO:0000313|Proteomes:UP000186318}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01580 {ECO:0000313|EMBL:OKJ32041.1,
RC   ECO:0000313|Proteomes:UP000186318};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004953}.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005879}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKJ32041.1}.
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DR   EMBL; LIXJ01000019; OKJ32041.1; -; Genomic_DNA.
DR   RefSeq; WP_073788463.1; NZ_LIXJ01000019.1.
DR   AlphaFoldDB; A0A1Q5GHF3; -.
DR   STRING; 1703933.AMK22_24090; -.
DR   OrthoDB; 9804789at2; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000186318; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR   Gene3D; 3.40.50.11220; -; 1.
DR   Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR021744; CbiG_N.
DR   InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR   InterPro; IPR002750; CobE/GbiG_C.
DR   InterPro; IPR036518; CobE/GbiG_C_sf.
DR   InterPro; IPR038029; GbiG_N_sf.
DR   NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR   PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF01890; CbiG_C; 1.
DR   Pfam; PF11760; CbiG_N; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR   SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:OKJ32041.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186318};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          37..116
FT                   /note="Cobalamin synthesis G N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11760"
FT   DOMAIN          200..324
FT                   /note="CobE/GbiG C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01890"
FT   DOMAIN          332..537
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
SQ   SEQUENCE   581 AA;  58971 MW;  D380E8FCE39D36BA CRC64;
     MIGLISATAA GAAARDRLAA AWPGRAVVYE GPVRAAVHRA FAECEQLVCF LATGAVVRLL
     APLLSDKSAD PGVVCVDEAG RHAVALLGGH AGGANALAEA VAEVLDATPV VTTATDAAGL
     LGLDMLGLPV EGDVAGVSRA MLDGAPVELR ADALWPLPAL PPNVAPGSTL PDPADAAVLH
     ITDRVVESGA RRAVVRPASL AVGVGASRGA PVDEVVGLVH DALREAGLSP LSIAELVTVD
     AKADEPGIVA AAARLGVPLR TYAAEALARV EVPNPSGAPL AAVGTPSVAE AAALVEGGEL
     LVPKRKSTPP PGSEGRAAMA TCAVVRRAPR GRLAVVGLGP GARDLLTPRA REELRRASVL
     VGLDQYVDQI RDLLRPGTTV LESGLGAEEE RARTAVAEAR EGRAVALIGS GDAGVYAMAS
     PALAEAGADI DVVGVPGVTA ALAAAAVLGA PLGHDHVSIS LSDLHTPWEV IERRVRAAAE
     ADIVVTFYNP RSRGRAWQLP EALSILAEHR DPATPVGVVR NASRPDESAR VTSLAALDPA
     AVDMMTVVTV GNTATRQIAG RMVTPRGYRW QSAAGTGEGG R
//
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