ID A0A1Q5GPR4_9ACTN Unreviewed; 1333 AA.
AC A0A1Q5GPR4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=ATP-dependent helicase {ECO:0000313|EMBL:OKJ34573.1};
GN ORFNames=AMK22_18740 {ECO:0000313|EMBL:OKJ34573.1};
OS Streptomyces sp. CB01580.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703933 {ECO:0000313|EMBL:OKJ34573.1, ECO:0000313|Proteomes:UP000186318};
RN [1] {ECO:0000313|EMBL:OKJ34573.1, ECO:0000313|Proteomes:UP000186318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01580 {ECO:0000313|EMBL:OKJ34573.1,
RC ECO:0000313|Proteomes:UP000186318};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ34573.1}.
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DR EMBL; LIXJ01000012; OKJ34573.1; -; Genomic_DNA.
DR RefSeq; WP_073786656.1; NZ_LIXJ01000012.1.
DR STRING; 1703933.AMK22_18740; -.
DR OrthoDB; 9805617at2; -.
DR Proteomes; UP000186318; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd17989; DEXHc_HrpA; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR024590; HrpA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11898; DUF3418; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:OKJ34573.1};
KW Hydrolase {ECO:0000313|EMBL:OKJ34573.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186318}.
FT DOMAIN 83..247
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 278..445
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 479..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1333 AA; 151119 MW; 10B8620EB4C01AA1 CRC64;
MSTSFADLQS RLEELSLRDA HRLGRRLEGA RRIRKPEARQ AVLDEIATEA GKAAERLVLR
AGRVPAVSYP EQLPVSQKKD EILEAIRDHQ VVIVAGETGS GKTTQIPKIC MELGRGVRGM
IGHTQPRRIA ARTVAERVAD ELRTPLGEAV GWKVRFTDQV NPDATFVKLM TDGILLAEIQ
TDRELRAYDT IIIDEAHERS LNIDFLLGYL ARLLPRRPDL KVVITSATID PERFARHFGE
APIIEVSGRT YPVEVRYRPL LEEVTEDSAD ADRDQITAIC DAVDELQSEG PGDILVFLSG
EREIRDTADA LNKRNLRHTE VLPLYARLSH AEQHRVFQRH TGRRIVLATN VAETSLTVPG
IKYVIDPGTA RISRYSHRTK VQRLPIERIS QASANQRKGR CGRTSDGICI RLYSEDDFLT
RPEFTDPEIL RTNLASVILQ MTAAGLGDIE RFPFIDPPDH RNIRDGIQLL QELGALEQGE
KPAREVRAGE REARPEGKKG QRLTPLGRKL SQLPVDPRLA RMVIEAERNG CVREVMVIAA
ALSIQDPRER PAEKQTQADQ QHARFKDETS DFLAFLNLWR YIREQQKERG SSSFRRMCKQ
EYLNFLRIRE WQDIYAQLRT VVKQMGVQPN TEDAPEQSVH VSLLAGLLSH IGLKDTEKNE
YLGARNAKFA VFPGSALFKK QPRFVMSAEL VETSRLWARV NAKVEPEWIE PLAQHLLKHT
YSEPHWEKDQ AAVMAYERVT LYGVPIIAQR KVNFGRIDAE TSRDLFIRHA LVEGDWRTHH
QFFQDNRKLL GEVEELEHRA RRRDILVDDE TLFDFYDRRI PEHVVSGAHF DSWWKHKRRD
EPDALDFERS MLINEKAGAV TKDDYPDSWR QGKLKFRVTY QFEPGADADG VTVHIPLQVL
NQVTAEGFDW QIPGLREEVV TELIRSLPKP IRRHYVPAPN YAEKFLDRAV PSASGGPTSQ
QEPLTVTLAR ELQRMVGVPV TADDFDLSRV PDHLKITFRI VDERRRKVAE DKDLEALRLQ
LRPRARQALS KAAAATAGPS GESVERSGLT DWTIGTLNRV FETRRAGQPV KAYPALVDQG
ATVAVRLFDT EAEQQRAMWL GTRRLILLNV PVNPAKFASD RLSNQQKLAL SANPHGSVQA
LFEDCATAAA DRLIGAHGGP AWDEESYRKL YDKVRADLVA LTEHTVKQVQ QVLAAWQACE
RRLKATNSLV LAANVADVRK QLAGLVPAGF VTATGLRRLP DLMRYLVAAD RRLQQMPTAV
QRDTTRMEKV HEMQDEYAWL LEQLPQGRPV PQEVLDIRWM IEELRVSYFA HALGTAYPVS
DKRIVKAIDA AAP
//
