ID A0A1Q5HFX7_9ACTN Unreviewed; 710 AA.
AC A0A1Q5HFX7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Peptidase S9 {ECO:0000313|EMBL:OKJ43731.1};
GN ORFNames=AMK22_03705 {ECO:0000313|EMBL:OKJ43731.1};
OS Streptomyces sp. CB01580.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703933 {ECO:0000313|EMBL:OKJ43731.1, ECO:0000313|Proteomes:UP000186318};
RN [1] {ECO:0000313|EMBL:OKJ43731.1, ECO:0000313|Proteomes:UP000186318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01580 {ECO:0000313|EMBL:OKJ43731.1,
RC ECO:0000313|Proteomes:UP000186318};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ43731.1}.
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DR EMBL; LIXJ01000002; OKJ43731.1; -; Genomic_DNA.
DR RefSeq; WP_073781779.1; NZ_LIXJ01000002.1.
DR AlphaFoldDB; A0A1Q5HFX7; -.
DR STRING; 1703933.AMK22_03705; -.
DR OrthoDB; 9812921at2; -.
DR Proteomes; UP000186318; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF07676; PD40; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000186318}.
FT DOMAIN 114..346
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 506..707
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 710 AA; 76647 MW; DA36A5EEFFD13F23 CRC64;
MTSQQISFPR QHARTMRFSL GAPRAFTISP DGKRVVFLRS GSGTERSGRL WVLDLPEGGT
PTERVVADPE ALLGGSAERL SAQERARRER SREGSSGIVG YAVDAAAELA AFALSGKVYV
AELRAGTARA LPVPGPVIDP RPSPDGRHIA YVAKGALRVV GAEGDGDRAL AEPETGNVTY
GLAEFIAAEE MQRSRGFWWS PDSDRLLVAR VDDSPVRRWW IADPAHPDRT PAEVAYPAAG
TPNAEVGLFL ADLDGGRTEV VWDRAHYPYL AQVHWSSAGA PLLLVQARDQ RSQLHLAVDT
ETGATRTVHV DEDPIWLEIF PGVPAWAPDG RLVRIADEGG ARVLAVGDRL LTGAQLQLRA
VLDIGDSDIL VSASAGEEAA EAEIGETHVY RVNELGVERI SEEAGVHSAV RAGDVTVLAS
QSLQWPGVRA EVLRDGKRIA TIANFAQEPV LSPRVQFTEG GARRIPCAVL LPRDYKESDG
PLPVLMDPYG GPHARRVLAA HHAHLTSQWF ADQGFAVVVA DGRGTPGRSP AWEKAVKDDL
ALTLDDQVEA LHALAENYPL DLGRVAIRGW SFGGYLSALA VLRRPDVFHA AVVGAPVTDL
RLYDTHYTER YLGDPAEQPE VYAHTSLLTD EGLSKAAEQV RPMMIVHGLA DDNVVVAHSL
RLSSALLAAG RPHEVLPLSG VTHMTPQEQV AENLLLLQVD FLKRSLGLRD
//
