ID A0A1Q5HY07_9ACTN Unreviewed; 347 AA.
AC A0A1Q5HY07;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=SAM-dependent methyltransferase {ECO:0000313|EMBL:OKJ49738.1};
GN ORFNames=AMK29_34025 {ECO:0000313|EMBL:OKJ49738.1};
OS Streptomyces sp. CB02261.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703940 {ECO:0000313|EMBL:OKJ49738.1, ECO:0000313|Proteomes:UP000186742};
RN [1] {ECO:0000313|EMBL:OKJ49738.1, ECO:0000313|Proteomes:UP000186742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02261 {ECO:0000313|EMBL:OKJ49738.1,
RC ECO:0000313|Proteomes:UP000186742};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ49738.1}.
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DR EMBL; LIVX01000015; OKJ49738.1; -; Genomic_DNA.
DR RefSeq; WP_073820057.1; NZ_LIVX01000015.1.
DR AlphaFoldDB; A0A1Q5HY07; -.
DR OrthoDB; 9801363at2; -.
DR Proteomes; UP000186742; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR048711; Rv2258c-like_HTH.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45128:SF2; METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45128; METHYLTRANSFERASE TYPE 11; 1.
DR Pfam; PF21320; HTH_65; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:OKJ49738.1};
KW Transferase {ECO:0000313|EMBL:OKJ49738.1}.
FT DOMAIN 20..89
FT /note="S-adenosylmethionine-dependent methyltransferase
FT Rv2258c-like winged HTH"
FT /evidence="ECO:0000259|Pfam:PF21320"
FT DOMAIN 167..279
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13847"
SQ SEQUENCE 347 AA; 37221 MW; FBB54A965E6F09ED CRC64;
MTAHDFHQRV ITDAGAAVRG LTVALGERLG LYKALAAGGP LTAGQLAEAT GTNERYVEEW
LHAQLSAGYV ERHPSSRTYT LPADHVEVLA DPKAVTYAAG FFTALKALYA TEDLLVEAYR
TGDGVGWAEH DAALDTGMGS FFQPTYEHKL VPEWLPALHQ VTDKLADGGT VADVGCGVGH
TTLLIARAFP NATVHGFDYS EEAISIAREL AEEAGLSDRV VFEVASADDY PGSGYDLVCF
FNALHDMGDP VAAARHVHKS LDADGTWMLV ESNVSPQDVD VQTPAARMFM ALSAVMCLPV
AVAQRGPHAL GNHSGEKAFR AIAEEAGFTR WRRATETPVN AVYEVRP
//
